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Roles of extracellular vesicles in periodontal homeostasis and their therapeutic potential
Periodontal tissue is a highly dynamic and frequently stimulated area where homeostasis is easily destroyed, leading to proinflammatory periodontal diseases. Bacteria–bacteria and cell–bacteria interactions play pivotal roles in periodontal homeostasis and disease progression. Several reviews have c...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9801622/ https://www.ncbi.nlm.nih.gov/pubmed/36585740 http://dx.doi.org/10.1186/s12951-022-01757-3 |
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author | Deng, Dao-Kun Zhang, Jiu-Jiu Gan, Dian Zou, Jie-Kang Wu, Rui-Xin Tian, Yi Yin, Yuan Li, Xuan Chen, Fa-Ming He, Xiao-Tao |
author_facet | Deng, Dao-Kun Zhang, Jiu-Jiu Gan, Dian Zou, Jie-Kang Wu, Rui-Xin Tian, Yi Yin, Yuan Li, Xuan Chen, Fa-Ming He, Xiao-Tao |
author_sort | Deng, Dao-Kun |
collection | PubMed |
description | Periodontal tissue is a highly dynamic and frequently stimulated area where homeostasis is easily destroyed, leading to proinflammatory periodontal diseases. Bacteria–bacteria and cell–bacteria interactions play pivotal roles in periodontal homeostasis and disease progression. Several reviews have comprehensively summarized the roles of bacteria and stem cells in periodontal homeostasis. However, they did not describe the roles of extracellular vesicles (EVs) from bacteria and cells. As communication mediators evolutionarily conserved from bacteria to eukaryotic cells, EVs secreted by bacteria or cells can mediate interactions between bacteria and their hosts, thereby offering great promise for the maintenance of periodontal homeostasis. This review offers an overview of EV biogenesis, the effects of EVs on periodontal homeostasis, and recent advances in EV-based periodontal regenerative strategies. Specifically, we document the pathogenic roles of bacteria-derived EVs (BEVs) in periodontal dyshomeostasis, focusing on plaque biofilm formation, immune evasion, inflammatory pathway activation and tissue destruction. Moreover, we summarize recent advancements in cell-derived EVs (CEVs) in periodontal homeostasis, emphasizing the multifunctional biological effects of CEVs on periodontal tissue regeneration. Finally, we discuss future challenges and practical perspectives for the clinical translation of EV-based therapies for periodontitis. GRAPHICAL ABSTRACT: [Image: see text] |
format | Online Article Text |
id | pubmed-9801622 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-98016222022-12-31 Roles of extracellular vesicles in periodontal homeostasis and their therapeutic potential Deng, Dao-Kun Zhang, Jiu-Jiu Gan, Dian Zou, Jie-Kang Wu, Rui-Xin Tian, Yi Yin, Yuan Li, Xuan Chen, Fa-Ming He, Xiao-Tao J Nanobiotechnology Review Periodontal tissue is a highly dynamic and frequently stimulated area where homeostasis is easily destroyed, leading to proinflammatory periodontal diseases. Bacteria–bacteria and cell–bacteria interactions play pivotal roles in periodontal homeostasis and disease progression. Several reviews have comprehensively summarized the roles of bacteria and stem cells in periodontal homeostasis. However, they did not describe the roles of extracellular vesicles (EVs) from bacteria and cells. As communication mediators evolutionarily conserved from bacteria to eukaryotic cells, EVs secreted by bacteria or cells can mediate interactions between bacteria and their hosts, thereby offering great promise for the maintenance of periodontal homeostasis. This review offers an overview of EV biogenesis, the effects of EVs on periodontal homeostasis, and recent advances in EV-based periodontal regenerative strategies. Specifically, we document the pathogenic roles of bacteria-derived EVs (BEVs) in periodontal dyshomeostasis, focusing on plaque biofilm formation, immune evasion, inflammatory pathway activation and tissue destruction. Moreover, we summarize recent advancements in cell-derived EVs (CEVs) in periodontal homeostasis, emphasizing the multifunctional biological effects of CEVs on periodontal tissue regeneration. Finally, we discuss future challenges and practical perspectives for the clinical translation of EV-based therapies for periodontitis. GRAPHICAL ABSTRACT: [Image: see text] BioMed Central 2022-12-30 /pmc/articles/PMC9801622/ /pubmed/36585740 http://dx.doi.org/10.1186/s12951-022-01757-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Deng, Dao-Kun Zhang, Jiu-Jiu Gan, Dian Zou, Jie-Kang Wu, Rui-Xin Tian, Yi Yin, Yuan Li, Xuan Chen, Fa-Ming He, Xiao-Tao Roles of extracellular vesicles in periodontal homeostasis and their therapeutic potential |
title | Roles of extracellular vesicles in periodontal homeostasis and their therapeutic potential |
title_full | Roles of extracellular vesicles in periodontal homeostasis and their therapeutic potential |
title_fullStr | Roles of extracellular vesicles in periodontal homeostasis and their therapeutic potential |
title_full_unstemmed | Roles of extracellular vesicles in periodontal homeostasis and their therapeutic potential |
title_short | Roles of extracellular vesicles in periodontal homeostasis and their therapeutic potential |
title_sort | roles of extracellular vesicles in periodontal homeostasis and their therapeutic potential |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9801622/ https://www.ncbi.nlm.nih.gov/pubmed/36585740 http://dx.doi.org/10.1186/s12951-022-01757-3 |
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