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Healthy birth in a case of total globozoospermia after intracytoplasmic sperm injection and assisted oocyte activation

Globozoospermia is a rare (incidence <0.1%) and very severe disorder, with major implications in male fertility. Total globozoospermia is represented by the presence of spermatozoa with 100% rounded heads and a lack of acrosomes. These specific morphological modifications seem to be connected to...

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Autores principales: Porumb, Ionuţ George, Coricovac, Anca Magdalena, Raica, Ioana Iulia, Zărnescu, Otilia, Didilescu, Andreea Cristiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9801671/
https://www.ncbi.nlm.nih.gov/pubmed/36374151
http://dx.doi.org/10.47162/RJME.63.2.17
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author Porumb, Ionuţ George
Coricovac, Anca Magdalena
Raica, Ioana Iulia
Zărnescu, Otilia
Didilescu, Andreea Cristiana
author_facet Porumb, Ionuţ George
Coricovac, Anca Magdalena
Raica, Ioana Iulia
Zărnescu, Otilia
Didilescu, Andreea Cristiana
author_sort Porumb, Ionuţ George
collection PubMed
description Globozoospermia is a rare (incidence <0.1%) and very severe disorder, with major implications in male fertility. Total globozoospermia is represented by the presence of spermatozoa with 100% rounded heads and a lack of acrosomes. These specific morphological modifications seem to be connected to defects occurring in the last stage of spermatogenesis, spermiogenesis, and will result in anomalies of the acrosomal reaction and a defective adherence of the spermatozoa to the oocytes zona pellucida. This will result in a failure of natural fertilization. This article aims to present the case of a couple diagnosed and successfully treated for primary male infertility. The 26-year-old male partner underwent two semen analyses that revealed the presence of fully rounded spermatozoa heads (morphological abnormality) and consequently was proposed for in vitro fertilization treatment. Semen preparation and the use of assisted reproductive techniques, intracytoplasmic injection of sperm cells into the assisted oocyte activation, have resulted in the conceivement of a healthy child. The particularities of this case lie in the early recognition of the total abnormal globozoospermia morphology. This is the first case reported in Romania where specific assisted reproductive techniques and treatments have resulted in a successful pregnancy for a couple with male total globozoospermia.
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spelling pubmed-98016712023-02-08 Healthy birth in a case of total globozoospermia after intracytoplasmic sperm injection and assisted oocyte activation Porumb, Ionuţ George Coricovac, Anca Magdalena Raica, Ioana Iulia Zărnescu, Otilia Didilescu, Andreea Cristiana Rom J Morphol Embryol Case Report Globozoospermia is a rare (incidence <0.1%) and very severe disorder, with major implications in male fertility. Total globozoospermia is represented by the presence of spermatozoa with 100% rounded heads and a lack of acrosomes. These specific morphological modifications seem to be connected to defects occurring in the last stage of spermatogenesis, spermiogenesis, and will result in anomalies of the acrosomal reaction and a defective adherence of the spermatozoa to the oocytes zona pellucida. This will result in a failure of natural fertilization. This article aims to present the case of a couple diagnosed and successfully treated for primary male infertility. The 26-year-old male partner underwent two semen analyses that revealed the presence of fully rounded spermatozoa heads (morphological abnormality) and consequently was proposed for in vitro fertilization treatment. Semen preparation and the use of assisted reproductive techniques, intracytoplasmic injection of sperm cells into the assisted oocyte activation, have resulted in the conceivement of a healthy child. The particularities of this case lie in the early recognition of the total abnormal globozoospermia morphology. This is the first case reported in Romania where specific assisted reproductive techniques and treatments have resulted in a successful pregnancy for a couple with male total globozoospermia. Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest 2022 2022-06-30 /pmc/articles/PMC9801671/ /pubmed/36374151 http://dx.doi.org/10.47162/RJME.63.2.17 Text en Copyright © 2022, Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited.
spellingShingle Case Report
Porumb, Ionuţ George
Coricovac, Anca Magdalena
Raica, Ioana Iulia
Zărnescu, Otilia
Didilescu, Andreea Cristiana
Healthy birth in a case of total globozoospermia after intracytoplasmic sperm injection and assisted oocyte activation
title Healthy birth in a case of total globozoospermia after intracytoplasmic sperm injection and assisted oocyte activation
title_full Healthy birth in a case of total globozoospermia after intracytoplasmic sperm injection and assisted oocyte activation
title_fullStr Healthy birth in a case of total globozoospermia after intracytoplasmic sperm injection and assisted oocyte activation
title_full_unstemmed Healthy birth in a case of total globozoospermia after intracytoplasmic sperm injection and assisted oocyte activation
title_short Healthy birth in a case of total globozoospermia after intracytoplasmic sperm injection and assisted oocyte activation
title_sort healthy birth in a case of total globozoospermia after intracytoplasmic sperm injection and assisted oocyte activation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9801671/
https://www.ncbi.nlm.nih.gov/pubmed/36374151
http://dx.doi.org/10.47162/RJME.63.2.17
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