Full, Partial, and Modified Permutations of the Mayo Score: Characterizing Clinical and Patient-Reported Outcomes in Ulcerative Colitis Patients

BACKGROUND: Understanding ulcerative colitis disease activity assessed via the full, modified, or partial Mayo Score may help clinicians apply results from clinical trials to practice and facilitate interpretation of recent and older studies. METHODS: Mayo Score variables were assessed in a cross-se...

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Autores principales: Naegeli, April N, Hunter, Theresa, Dong, Yan, Hoskin, Ben, Middleton-Dalby, Chloe, Hetherington, James, Stefani-Hunyady, Diana, Canavan, James B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Observations and Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802037/
https://www.ncbi.nlm.nih.gov/pubmed/36777063
http://dx.doi.org/10.1093/crocol/otab007
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author Naegeli, April N
Hunter, Theresa
Dong, Yan
Hoskin, Ben
Middleton-Dalby, Chloe
Hetherington, James
Stefani-Hunyady, Diana
Canavan, James B
author_facet Naegeli, April N
Hunter, Theresa
Dong, Yan
Hoskin, Ben
Middleton-Dalby, Chloe
Hetherington, James
Stefani-Hunyady, Diana
Canavan, James B
author_sort Naegeli, April N
collection PubMed
description BACKGROUND: Understanding ulcerative colitis disease activity assessed via the full, modified, or partial Mayo Score may help clinicians apply results from clinical trials to practice and facilitate interpretation of recent and older studies. METHODS: Mayo Score variables were assessed in a cross-sectional study of 2608 ulcerative colitis patients. RESULTS: Permutations of Mayo Scores were highly correlated, and models predicting the omitted variable from each permutation demonstrated significant agreement between predicted and observed values. CONCLUSIONS: Partial/modified Mayo Scores may be used to predict endoscopic and Physician’s Global Assessment scores, and serve as proxies for the full Mayo Score in clinical practice/trials.
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spelling pubmed-98020372023-02-10 Full, Partial, and Modified Permutations of the Mayo Score: Characterizing Clinical and Patient-Reported Outcomes in Ulcerative Colitis Patients Naegeli, April N Hunter, Theresa Dong, Yan Hoskin, Ben Middleton-Dalby, Chloe Hetherington, James Stefani-Hunyady, Diana Canavan, James B Crohns Colitis 360 Observations and Research BACKGROUND: Understanding ulcerative colitis disease activity assessed via the full, modified, or partial Mayo Score may help clinicians apply results from clinical trials to practice and facilitate interpretation of recent and older studies. METHODS: Mayo Score variables were assessed in a cross-sectional study of 2608 ulcerative colitis patients. RESULTS: Permutations of Mayo Scores were highly correlated, and models predicting the omitted variable from each permutation demonstrated significant agreement between predicted and observed values. CONCLUSIONS: Partial/modified Mayo Scores may be used to predict endoscopic and Physician’s Global Assessment scores, and serve as proxies for the full Mayo Score in clinical practice/trials. Oxford University Press 2021-02-23 /pmc/articles/PMC9802037/ /pubmed/36777063 http://dx.doi.org/10.1093/crocol/otab007 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of Crohn's & Colitis Foundation. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Observations and Research
Naegeli, April N
Hunter, Theresa
Dong, Yan
Hoskin, Ben
Middleton-Dalby, Chloe
Hetherington, James
Stefani-Hunyady, Diana
Canavan, James B
Full, Partial, and Modified Permutations of the Mayo Score: Characterizing Clinical and Patient-Reported Outcomes in Ulcerative Colitis Patients
title Full, Partial, and Modified Permutations of the Mayo Score: Characterizing Clinical and Patient-Reported Outcomes in Ulcerative Colitis Patients
title_full Full, Partial, and Modified Permutations of the Mayo Score: Characterizing Clinical and Patient-Reported Outcomes in Ulcerative Colitis Patients
title_fullStr Full, Partial, and Modified Permutations of the Mayo Score: Characterizing Clinical and Patient-Reported Outcomes in Ulcerative Colitis Patients
title_full_unstemmed Full, Partial, and Modified Permutations of the Mayo Score: Characterizing Clinical and Patient-Reported Outcomes in Ulcerative Colitis Patients
title_short Full, Partial, and Modified Permutations of the Mayo Score: Characterizing Clinical and Patient-Reported Outcomes in Ulcerative Colitis Patients
title_sort full, partial, and modified permutations of the mayo score: characterizing clinical and patient-reported outcomes in ulcerative colitis patients
topic Observations and Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802037/
https://www.ncbi.nlm.nih.gov/pubmed/36777063
http://dx.doi.org/10.1093/crocol/otab007
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