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Sustained degradation of hyaluronic acid using an in situ forming implant

In pancreatic cancer, excessive hyaluronic acid (HA) in the tumor microenvironment creates a viscous stroma, which reduces systemic drug transport into the tumor and correlates with poor patient prognosis. HA can be degraded through both enzymatic and nonenzymatic methods to improve mass transport p...

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Detalles Bibliográficos
Autores principales:	Hopkins, Kelsey, Buno, Kevin, Romick, Natalie, Freitas dos Santos, Antonio Carlos, Tinsley, Samantha, Wakelin, Elizabeth, Kennedy, Jacqueline, Ladisch, Michael, Allen-Petersen, Brittany L, Solorio, Luis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Physical Sciences and Engineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802073/ https://www.ncbi.nlm.nih.gov/pubmed/36714867 http://dx.doi.org/10.1093/pnasnexus/pgac193

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