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Association Between Inflammatory Bowel Disease and Pruritus

BACKGROUND: Inflammatory bowel disease (IBD) is often complicated by extraintestinal manifestations. We frequently encounter IBD patients with pruritus; however, clinical evidence for the association of these conditions is lacking. Therefore, the present study investigated the incidence of pruritus...

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Autores principales: Iwamoto, Shiho, Tominaga, Mitsutoshi, Kamata, Yayoi, Kawakami, Tomohiro, Osada, Taro, Takamori, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802076/
https://www.ncbi.nlm.nih.gov/pubmed/36777956
http://dx.doi.org/10.1093/crocol/otaa012
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author Iwamoto, Shiho
Tominaga, Mitsutoshi
Kamata, Yayoi
Kawakami, Tomohiro
Osada, Taro
Takamori, Kenji
author_facet Iwamoto, Shiho
Tominaga, Mitsutoshi
Kamata, Yayoi
Kawakami, Tomohiro
Osada, Taro
Takamori, Kenji
author_sort Iwamoto, Shiho
collection PubMed
description BACKGROUND: Inflammatory bowel disease (IBD) is often complicated by extraintestinal manifestations. We frequently encounter IBD patients with pruritus; however, clinical evidence for the association of these conditions is lacking. Therefore, the present study investigated the incidence of pruritus in IBD patients. METHODS: Seventy-one IBD outpatients, including 55 with ulcerative colitis (UC) and 16 with Crohn disease, and 39 healthy volunteers (HVs) were surveyed about their pruritus symptoms using a visual analogue scale (VAS). Disease activities in UC and Crohn disease patients were classified according to partial Mayo and IOIBD (International Organization for the Study of inflammatory Bowel Disease) scores, respectively. Skin barrier condition was examined by measuring transepidermal water loss and stratum corneum hydration. The distribution of intraepidermal nerve fibers in skin samples from 9 UC patients was examined immunohistochemically using an antiprotein gene product (PGP) 9.5 antibody. RESULTS: Visual analogue scale scores were higher in IBD patients than in HV (P < 0.001). Active stage IBD patients had more severe pruritus VAS scores than those in the remission stage (P = 0.036). Transepidermal water loss was higher in IBD patients (P < 0.001) and active stage IBD patients (P = 0.004), while stratum corneum hydration was lower in IBD patients (P = 0.019) and active stage IBD patients than in HV (P = 0.019). A relationship was observed between the degree of pruritus and number of PGP9.5-immunoreactive intraepidermal nerve fibers in UC patients. CONCLUSIONS: Inflammatory bowel disease patients, particularly active stage patients, frequently exhibit symptoms of pruritus and dry skin. This result may have predictive and therapeutic implications for the treatment of IBD symptoms.
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spelling pubmed-98020762023-02-10 Association Between Inflammatory Bowel Disease and Pruritus Iwamoto, Shiho Tominaga, Mitsutoshi Kamata, Yayoi Kawakami, Tomohiro Osada, Taro Takamori, Kenji Crohns Colitis 360 Observations and Research BACKGROUND: Inflammatory bowel disease (IBD) is often complicated by extraintestinal manifestations. We frequently encounter IBD patients with pruritus; however, clinical evidence for the association of these conditions is lacking. Therefore, the present study investigated the incidence of pruritus in IBD patients. METHODS: Seventy-one IBD outpatients, including 55 with ulcerative colitis (UC) and 16 with Crohn disease, and 39 healthy volunteers (HVs) were surveyed about their pruritus symptoms using a visual analogue scale (VAS). Disease activities in UC and Crohn disease patients were classified according to partial Mayo and IOIBD (International Organization for the Study of inflammatory Bowel Disease) scores, respectively. Skin barrier condition was examined by measuring transepidermal water loss and stratum corneum hydration. The distribution of intraepidermal nerve fibers in skin samples from 9 UC patients was examined immunohistochemically using an antiprotein gene product (PGP) 9.5 antibody. RESULTS: Visual analogue scale scores were higher in IBD patients than in HV (P < 0.001). Active stage IBD patients had more severe pruritus VAS scores than those in the remission stage (P = 0.036). Transepidermal water loss was higher in IBD patients (P < 0.001) and active stage IBD patients (P = 0.004), while stratum corneum hydration was lower in IBD patients (P = 0.019) and active stage IBD patients than in HV (P = 0.019). A relationship was observed between the degree of pruritus and number of PGP9.5-immunoreactive intraepidermal nerve fibers in UC patients. CONCLUSIONS: Inflammatory bowel disease patients, particularly active stage patients, frequently exhibit symptoms of pruritus and dry skin. This result may have predictive and therapeutic implications for the treatment of IBD symptoms. Oxford University Press 2020-02-28 /pmc/articles/PMC9802076/ /pubmed/36777956 http://dx.doi.org/10.1093/crocol/otaa012 Text en © 2020 Crohn’s & Colitis Foundation. Published by Oxford University Press on behalf of Crohn's & Colitis Foundation. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Observations and Research
Iwamoto, Shiho
Tominaga, Mitsutoshi
Kamata, Yayoi
Kawakami, Tomohiro
Osada, Taro
Takamori, Kenji
Association Between Inflammatory Bowel Disease and Pruritus
title Association Between Inflammatory Bowel Disease and Pruritus
title_full Association Between Inflammatory Bowel Disease and Pruritus
title_fullStr Association Between Inflammatory Bowel Disease and Pruritus
title_full_unstemmed Association Between Inflammatory Bowel Disease and Pruritus
title_short Association Between Inflammatory Bowel Disease and Pruritus
title_sort association between inflammatory bowel disease and pruritus
topic Observations and Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802076/
https://www.ncbi.nlm.nih.gov/pubmed/36777956
http://dx.doi.org/10.1093/crocol/otaa012
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