High-fidelity reprogramming into Leydig-like cells by CRISPR activation and paracrine factors

Androgen deficiency is a common medical conditions that affects males of all ages. Transplantation of testosterone-producing cells is a promising treatment for male hypogonadism. However, getting a cell source with the characteristics of Leydig cells (LCs) is still a challenge. Here, a high-efficien...

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Detalles Bibliográficos
Autores principales: Li, Zhaohui, Fan, Yuxiao, Xie, Cankun, Liu, Jierong, Guan, Xiaoju, Li, Shijun, Huang, Yadong, Zeng, Rong, Chen, Haolin, Su, Zhijian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Biological, Health, and Medical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802085/
https://www.ncbi.nlm.nih.gov/pubmed/36714877
http://dx.doi.org/10.1093/pnasnexus/pgac179

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