Long-Term Clinical Effectiveness of Ustekinumab in Patients With Crohn’s Disease: A Retrospective Cohort Study

BACKGROUND: This study clarifies the long-term effectiveness of ustekinumab based on real-life data from Japanese Crohn’s disease (CD) patients. METHODS: A total of 137 patients were included, and 124 patients (90.5%) were exposed to anti-tumor necrosis factor-α agents. RESULTS: The clinical remissi...

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Autores principales: Ito, Takahiro, Maemoto, Atsuo, Katsurada, Takehiko, Tanaka, Hiroki, Motoya, Satoshi, Ueno, Nobuhiro, Fujiya, Mikihiro, Ashida, Toshifumi, Hirayama, Daisuke, Nakase, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Observations and Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802107/
https://www.ncbi.nlm.nih.gov/pubmed/36777754
http://dx.doi.org/10.1093/crocol/otaa061
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author Ito, Takahiro
Maemoto, Atsuo
Katsurada, Takehiko
Tanaka, Hiroki
Motoya, Satoshi
Ueno, Nobuhiro
Fujiya, Mikihiro
Ashida, Toshifumi
Hirayama, Daisuke
Nakase, Hiroshi
author_facet Ito, Takahiro
Maemoto, Atsuo
Katsurada, Takehiko
Tanaka, Hiroki
Motoya, Satoshi
Ueno, Nobuhiro
Fujiya, Mikihiro
Ashida, Toshifumi
Hirayama, Daisuke
Nakase, Hiroshi
author_sort Ito, Takahiro
collection PubMed
description BACKGROUND: This study clarifies the long-term effectiveness of ustekinumab based on real-life data from Japanese Crohn’s disease (CD) patients. METHODS: A total of 137 patients were included, and 124 patients (90.5%) were exposed to anti-tumor necrosis factor-α agents. RESULTS: The clinical remission rate at week 52 was 32.4% in moderate to severely active CD patients. The achievement of clinical remission for 8 weeks after ustekinumab therapy induction was associated with clinical remission at week 52. Ustekinumab persistence rate at week 104 was 81.4%. CONCLUSION: Ustekinumab is effective and persistent in CD patients with the previous treatment history of several biologics.
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spelling pubmed-98021072023-02-10 Long-Term Clinical Effectiveness of Ustekinumab in Patients With Crohn’s Disease: A Retrospective Cohort Study Ito, Takahiro Maemoto, Atsuo Katsurada, Takehiko Tanaka, Hiroki Motoya, Satoshi Ueno, Nobuhiro Fujiya, Mikihiro Ashida, Toshifumi Hirayama, Daisuke Nakase, Hiroshi Crohns Colitis 360 Observations and Research BACKGROUND: This study clarifies the long-term effectiveness of ustekinumab based on real-life data from Japanese Crohn’s disease (CD) patients. METHODS: A total of 137 patients were included, and 124 patients (90.5%) were exposed to anti-tumor necrosis factor-α agents. RESULTS: The clinical remission rate at week 52 was 32.4% in moderate to severely active CD patients. The achievement of clinical remission for 8 weeks after ustekinumab therapy induction was associated with clinical remission at week 52. Ustekinumab persistence rate at week 104 was 81.4%. CONCLUSION: Ustekinumab is effective and persistent in CD patients with the previous treatment history of several biologics. Oxford University Press 2020-07-28 /pmc/articles/PMC9802107/ /pubmed/36777754 http://dx.doi.org/10.1093/crocol/otaa061 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Crohn's & Colitis Foundation. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Observations and Research
Ito, Takahiro
Maemoto, Atsuo
Katsurada, Takehiko
Tanaka, Hiroki
Motoya, Satoshi
Ueno, Nobuhiro
Fujiya, Mikihiro
Ashida, Toshifumi
Hirayama, Daisuke
Nakase, Hiroshi
Long-Term Clinical Effectiveness of Ustekinumab in Patients With Crohn’s Disease: A Retrospective Cohort Study
title Long-Term Clinical Effectiveness of Ustekinumab in Patients With Crohn’s Disease: A Retrospective Cohort Study
title_full Long-Term Clinical Effectiveness of Ustekinumab in Patients With Crohn’s Disease: A Retrospective Cohort Study
title_fullStr Long-Term Clinical Effectiveness of Ustekinumab in Patients With Crohn’s Disease: A Retrospective Cohort Study
title_full_unstemmed Long-Term Clinical Effectiveness of Ustekinumab in Patients With Crohn’s Disease: A Retrospective Cohort Study
title_short Long-Term Clinical Effectiveness of Ustekinumab in Patients With Crohn’s Disease: A Retrospective Cohort Study
title_sort long-term clinical effectiveness of ustekinumab in patients with crohn’s disease: a retrospective cohort study
topic Observations and Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802107/
https://www.ncbi.nlm.nih.gov/pubmed/36777754
http://dx.doi.org/10.1093/crocol/otaa061
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