Performance Characteristics of a Clinical Decision Support Tool for Disease Complications in Crohn’s Disease

BACKGROUND: Patients with Crohn’s disease (CD) are at risk of complications. Performance characteristics of a decision support tool assessing the risk of CD complications were evaluated. METHODS: CDPATH (formerly called the Personalized Risk and Outcome Prediction Tool [PROSPECT]) was calibrated and...

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Autores principales: Siegel, Corey A, Siegel, Lori S, Dubinsky, Marla C, Targan, Stephan, Braun, Jonathan, Landers, Carol, Bilsborough, Janine, Princen, Fred, Lasch, Karen, Candela, Ninfa, McGovern, Dermot P B, Dervieux, Thierry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Observations and Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802159/
https://www.ncbi.nlm.nih.gov/pubmed/36777269
http://dx.doi.org/10.1093/crocol/otab074
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author Siegel, Corey A
Siegel, Lori S
Dubinsky, Marla C
Targan, Stephan
Braun, Jonathan
Landers, Carol
Bilsborough, Janine
Princen, Fred
Lasch, Karen
Candela, Ninfa
McGovern, Dermot P B
Dervieux, Thierry
author_facet Siegel, Corey A
Siegel, Lori S
Dubinsky, Marla C
Targan, Stephan
Braun, Jonathan
Landers, Carol
Bilsborough, Janine
Princen, Fred
Lasch, Karen
Candela, Ninfa
McGovern, Dermot P B
Dervieux, Thierry
author_sort Siegel, Corey A
collection PubMed
description BACKGROUND: Patients with Crohn’s disease (CD) are at risk of complications. Performance characteristics of a decision support tool assessing the risk of CD complications were evaluated. METHODS: CDPATH (formerly called the Personalized Risk and Outcome Prediction Tool [PROSPECT]) was calibrated and validated in 2 cohorts. Tool prediction of disease characteristics was assessed using Cox regression and Harrell’s C-statistic. RESULTS: All associations of CD complications and CDPATH components were significant except perianal location. There was a significant association between individualized risk assessment scores and CD complications in both cohorts. CONCLUSION: CDPATH is validated as a clinical decision support tool for assessing the risk of CD complications.
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spelling pubmed-98021592023-02-10 Performance Characteristics of a Clinical Decision Support Tool for Disease Complications in Crohn’s Disease Siegel, Corey A Siegel, Lori S Dubinsky, Marla C Targan, Stephan Braun, Jonathan Landers, Carol Bilsborough, Janine Princen, Fred Lasch, Karen Candela, Ninfa McGovern, Dermot P B Dervieux, Thierry Crohns Colitis 360 Observations and Research BACKGROUND: Patients with Crohn’s disease (CD) are at risk of complications. Performance characteristics of a decision support tool assessing the risk of CD complications were evaluated. METHODS: CDPATH (formerly called the Personalized Risk and Outcome Prediction Tool [PROSPECT]) was calibrated and validated in 2 cohorts. Tool prediction of disease characteristics was assessed using Cox regression and Harrell’s C-statistic. RESULTS: All associations of CD complications and CDPATH components were significant except perianal location. There was a significant association between individualized risk assessment scores and CD complications in both cohorts. CONCLUSION: CDPATH is validated as a clinical decision support tool for assessing the risk of CD complications. Oxford University Press 2021-10-30 /pmc/articles/PMC9802159/ /pubmed/36777269 http://dx.doi.org/10.1093/crocol/otab074 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of Crohn\'s & Colitis Foundation. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Observations and Research
Siegel, Corey A
Siegel, Lori S
Dubinsky, Marla C
Targan, Stephan
Braun, Jonathan
Landers, Carol
Bilsborough, Janine
Princen, Fred
Lasch, Karen
Candela, Ninfa
McGovern, Dermot P B
Dervieux, Thierry
Performance Characteristics of a Clinical Decision Support Tool for Disease Complications in Crohn’s Disease
title Performance Characteristics of a Clinical Decision Support Tool for Disease Complications in Crohn’s Disease
title_full Performance Characteristics of a Clinical Decision Support Tool for Disease Complications in Crohn’s Disease
title_fullStr Performance Characteristics of a Clinical Decision Support Tool for Disease Complications in Crohn’s Disease
title_full_unstemmed Performance Characteristics of a Clinical Decision Support Tool for Disease Complications in Crohn’s Disease
title_short Performance Characteristics of a Clinical Decision Support Tool for Disease Complications in Crohn’s Disease
title_sort performance characteristics of a clinical decision support tool for disease complications in crohn’s disease
topic Observations and Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802159/
https://www.ncbi.nlm.nih.gov/pubmed/36777269
http://dx.doi.org/10.1093/crocol/otab074
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