Efficacy of Calcineurin Inhibitors for Induction of Remission in Intestinal Behçet’s Disease

BACKGROUND: The efficacy of calcineurin inhibitors (CNIs) for induction of remission in intestinal Behçet’s disease (intestinal BD) has not been explored. METHODS: A multicenter retrospective case series study of patients with active intestinal BD treated with CNIs (cyclosporin and tacrolimus) was c...

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Detalles Bibliográficos
Autores principales: Kawaguchi, Takaaki, Fukata, Masayuki, Omori, Teppei, Kiyohara, Hiroki, Sugimoto, Shinya, Nanki, Kosaku, Sujino, Tomohisa, Mikami, Yohei, Kanai, Takanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Case Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802215/
https://www.ncbi.nlm.nih.gov/pubmed/36777415
http://dx.doi.org/10.1093/crocol/otac017
Descripción
Sumario:BACKGROUND: The efficacy of calcineurin inhibitors (CNIs) for induction of remission in intestinal Behçet’s disease (intestinal BD) has not been explored. METHODS: A multicenter retrospective case series study of patients with active intestinal BD treated with CNIs (cyclosporin and tacrolimus) was conducted. RESULTS: Of 16 patients, 12 (75%) showed a clinical response and 5 (31.3%) achieved clinical remission after 2 weeks of CNI treatment. Similar efficacy of CNIs was observed even in 7 patients refractory to antitumor necrosis factor-alpha therapies. Endoscopic improvement was observed in 11 of 12 patients. CONCLUSIONS: CNIs may be promising treatment options for refractory intestinal BD.

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