Efficacy of Calcineurin Inhibitors for Induction of Remission in Intestinal Behçet’s Disease

BACKGROUND: The efficacy of calcineurin inhibitors (CNIs) for induction of remission in intestinal Behçet’s disease (intestinal BD) has not been explored. METHODS: A multicenter retrospective case series study of patients with active intestinal BD treated with CNIs (cyclosporin and tacrolimus) was c...

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Autores principales: Kawaguchi, Takaaki, Fukata, Masayuki, Omori, Teppei, Kiyohara, Hiroki, Sugimoto, Shinya, Nanki, Kosaku, Sujino, Tomohisa, Mikami, Yohei, Kanai, Takanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Case Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802215/
https://www.ncbi.nlm.nih.gov/pubmed/36777415
http://dx.doi.org/10.1093/crocol/otac017
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author Kawaguchi, Takaaki
Fukata, Masayuki
Omori, Teppei
Kiyohara, Hiroki
Sugimoto, Shinya
Nanki, Kosaku
Sujino, Tomohisa
Mikami, Yohei
Kanai, Takanori
author_facet Kawaguchi, Takaaki
Fukata, Masayuki
Omori, Teppei
Kiyohara, Hiroki
Sugimoto, Shinya
Nanki, Kosaku
Sujino, Tomohisa
Mikami, Yohei
Kanai, Takanori
author_sort Kawaguchi, Takaaki
collection PubMed
description BACKGROUND: The efficacy of calcineurin inhibitors (CNIs) for induction of remission in intestinal Behçet’s disease (intestinal BD) has not been explored. METHODS: A multicenter retrospective case series study of patients with active intestinal BD treated with CNIs (cyclosporin and tacrolimus) was conducted. RESULTS: Of 16 patients, 12 (75%) showed a clinical response and 5 (31.3%) achieved clinical remission after 2 weeks of CNI treatment. Similar efficacy of CNIs was observed even in 7 patients refractory to antitumor necrosis factor-alpha therapies. Endoscopic improvement was observed in 11 of 12 patients. CONCLUSIONS: CNIs may be promising treatment options for refractory intestinal BD.
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spelling pubmed-98022152023-02-10 Efficacy of Calcineurin Inhibitors for Induction of Remission in Intestinal Behçet’s Disease Kawaguchi, Takaaki Fukata, Masayuki Omori, Teppei Kiyohara, Hiroki Sugimoto, Shinya Nanki, Kosaku Sujino, Tomohisa Mikami, Yohei Kanai, Takanori Crohns Colitis 360 Case Proceedings BACKGROUND: The efficacy of calcineurin inhibitors (CNIs) for induction of remission in intestinal Behçet’s disease (intestinal BD) has not been explored. METHODS: A multicenter retrospective case series study of patients with active intestinal BD treated with CNIs (cyclosporin and tacrolimus) was conducted. RESULTS: Of 16 patients, 12 (75%) showed a clinical response and 5 (31.3%) achieved clinical remission after 2 weeks of CNI treatment. Similar efficacy of CNIs was observed even in 7 patients refractory to antitumor necrosis factor-alpha therapies. Endoscopic improvement was observed in 11 of 12 patients. CONCLUSIONS: CNIs may be promising treatment options for refractory intestinal BD. Oxford University Press 2022-06-02 /pmc/articles/PMC9802215/ /pubmed/36777415 http://dx.doi.org/10.1093/crocol/otac017 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Crohn's & Colitis Foundation. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Case Proceedings
Kawaguchi, Takaaki
Fukata, Masayuki
Omori, Teppei
Kiyohara, Hiroki
Sugimoto, Shinya
Nanki, Kosaku
Sujino, Tomohisa
Mikami, Yohei
Kanai, Takanori
Efficacy of Calcineurin Inhibitors for Induction of Remission in Intestinal Behçet’s Disease
title Efficacy of Calcineurin Inhibitors for Induction of Remission in Intestinal Behçet’s Disease
title_full Efficacy of Calcineurin Inhibitors for Induction of Remission in Intestinal Behçet’s Disease
title_fullStr Efficacy of Calcineurin Inhibitors for Induction of Remission in Intestinal Behçet’s Disease
title_full_unstemmed Efficacy of Calcineurin Inhibitors for Induction of Remission in Intestinal Behçet’s Disease
title_short Efficacy of Calcineurin Inhibitors for Induction of Remission in Intestinal Behçet’s Disease
title_sort efficacy of calcineurin inhibitors for induction of remission in intestinal behçet’s disease
topic Case Proceedings
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802215/
https://www.ncbi.nlm.nih.gov/pubmed/36777415
http://dx.doi.org/10.1093/crocol/otac017
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