The Genetics of Postoperative Recurrence in Crohn Disease: A Systematic Review, Meta-analysis, and Framework for Future Work

BACKGROUND: Recurrence following abdominal surgery in Crohn disease is over 50%. The impact of genetics on postoperative recurrence is not well defined. METHODS: A literature search was conducted where inclusion required an assessment, by genotype, of postoperative recurrence. The primary endpoint w...

Descripción completa

Detalles Bibliográficos
Autores principales: Dang, Jerry T, Dang, ThucNhi T, Wine, Eytan, Dicken, Bryan, Madsen, Karen, Laffin, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Observations and Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802308/
https://www.ncbi.nlm.nih.gov/pubmed/36778938
http://dx.doi.org/10.1093/crocol/otaa094
Descripción
Sumario:BACKGROUND: Recurrence following abdominal surgery in Crohn disease is over 50%. The impact of genetics on postoperative recurrence is not well defined. METHODS: A literature search was conducted where inclusion required an assessment, by genotype, of postoperative recurrence. The primary endpoint was odds of surgical recurrence. RESULTS: Twenty-eight studies identified a total of 6715 patients. Thirteen loci were identified as modifying the risk of recurrence. NOD2 was identified as a risk factor for recurrence by multiple works (cumulative odds ratio: 1.64, P = 0.003). CONCLUSIONS: A NOD2 risk allele is associated with recurrence following surgery in Crohn disease. Progress in this area will require standardized reporting in future works.

Ejemplares similares