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Hip osteoarthritis: A novel network analysis of subchondral trabecular bone structures

Hip osteoarthritis (HOA) is a degenerative joint disease that leads to the progressive destruction of subchondral bone and cartilage at the hip joint. Development of effective treatments for HOA remains an open problem, primarily due to the lack of knowledge of its pathogenesis and a typically late-...

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Autores principales: Dorraki, Mohsen, Muratovic, Dzenita, Fouladzadeh, Anahita, Verjans, Johan W, Allison, Andrew, Findlay, David M, Abbott, Derek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802325/
https://www.ncbi.nlm.nih.gov/pubmed/36712355
http://dx.doi.org/10.1093/pnasnexus/pgac258
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author Dorraki, Mohsen
Muratovic, Dzenita
Fouladzadeh, Anahita
Verjans, Johan W
Allison, Andrew
Findlay, David M
Abbott, Derek
author_facet Dorraki, Mohsen
Muratovic, Dzenita
Fouladzadeh, Anahita
Verjans, Johan W
Allison, Andrew
Findlay, David M
Abbott, Derek
author_sort Dorraki, Mohsen
collection PubMed
description Hip osteoarthritis (HOA) is a degenerative joint disease that leads to the progressive destruction of subchondral bone and cartilage at the hip joint. Development of effective treatments for HOA remains an open problem, primarily due to the lack of knowledge of its pathogenesis and a typically late-stage diagnosis. We describe a novel network analysis methodology for microcomputed tomography (micro-CT) images of human trabecular bone. We explored differences between the trabecular bone microstructure of femoral heads with and without HOA. Large-scale automated extraction of the network formed by trabecular bone revealed significant network properties not previously reported for bone. Profound differences were discovered, particularly in the proximal third of the femoral head, where HOA networks demonstrated elevated numbers of edges, vertices, and graph components. When further differentiating healthy joint and HOA networks, the latter showed fewer small-world network properties, due to decreased clustering coefficient and increased characteristic path length. Furthermore, we found that HOA networks had reduced length of edges, indicating the formation of compressed trabecular structures. In order to assess our network approach, we developed a deep learning model for classifying HOA and control cases, and we fed it with two separate inputs: (i) micro-CT images of the trabecular bone, and (ii) the network extracted from them. The model with plain micro-CT images achieves 74.6% overall accuracy while the trained model with extracted networks attains 96.5% accuracy. We anticipate our findings to be a starting point for a novel description of bone microstructure in HOA, by considering the phenomenon from a graph theory viewpoint.
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spelling pubmed-98023252023-01-26 Hip osteoarthritis: A novel network analysis of subchondral trabecular bone structures Dorraki, Mohsen Muratovic, Dzenita Fouladzadeh, Anahita Verjans, Johan W Allison, Andrew Findlay, David M Abbott, Derek PNAS Nexus Biological, Health, and Medical Sciences Hip osteoarthritis (HOA) is a degenerative joint disease that leads to the progressive destruction of subchondral bone and cartilage at the hip joint. Development of effective treatments for HOA remains an open problem, primarily due to the lack of knowledge of its pathogenesis and a typically late-stage diagnosis. We describe a novel network analysis methodology for microcomputed tomography (micro-CT) images of human trabecular bone. We explored differences between the trabecular bone microstructure of femoral heads with and without HOA. Large-scale automated extraction of the network formed by trabecular bone revealed significant network properties not previously reported for bone. Profound differences were discovered, particularly in the proximal third of the femoral head, where HOA networks demonstrated elevated numbers of edges, vertices, and graph components. When further differentiating healthy joint and HOA networks, the latter showed fewer small-world network properties, due to decreased clustering coefficient and increased characteristic path length. Furthermore, we found that HOA networks had reduced length of edges, indicating the formation of compressed trabecular structures. In order to assess our network approach, we developed a deep learning model for classifying HOA and control cases, and we fed it with two separate inputs: (i) micro-CT images of the trabecular bone, and (ii) the network extracted from them. The model with plain micro-CT images achieves 74.6% overall accuracy while the trained model with extracted networks attains 96.5% accuracy. We anticipate our findings to be a starting point for a novel description of bone microstructure in HOA, by considering the phenomenon from a graph theory viewpoint. Oxford University Press 2022-11-21 /pmc/articles/PMC9802325/ /pubmed/36712355 http://dx.doi.org/10.1093/pnasnexus/pgac258 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of National Academy of Sciences. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Biological, Health, and Medical Sciences
Dorraki, Mohsen
Muratovic, Dzenita
Fouladzadeh, Anahita
Verjans, Johan W
Allison, Andrew
Findlay, David M
Abbott, Derek
Hip osteoarthritis: A novel network analysis of subchondral trabecular bone structures
title Hip osteoarthritis: A novel network analysis of subchondral trabecular bone structures
title_full Hip osteoarthritis: A novel network analysis of subchondral trabecular bone structures
title_fullStr Hip osteoarthritis: A novel network analysis of subchondral trabecular bone structures
title_full_unstemmed Hip osteoarthritis: A novel network analysis of subchondral trabecular bone structures
title_short Hip osteoarthritis: A novel network analysis of subchondral trabecular bone structures
title_sort hip osteoarthritis: a novel network analysis of subchondral trabecular bone structures
topic Biological, Health, and Medical Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802325/
https://www.ncbi.nlm.nih.gov/pubmed/36712355
http://dx.doi.org/10.1093/pnasnexus/pgac258
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