Omicron variant of SARS-CoV-2 exhibits an increased resilience to the antiviral type I interferon response

The new variant of concern (VOC) of SARS-CoV-2, Omicron (B.1.1.529), is genetically very different from other VOCs. We compared Omicron with the preceding VOC Delta (B.1.617.2) and the wildtype (wt) strain (B.1) with respect to their interactions with the antiviral interferon (IFN-alpha/beta) respon...

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Detalles Bibliográficos
Autores principales: Shalamova, Lyudmila, Felgenhauer, Ulrike, Wilhelm, Jochen, Schaubmar, Andreas R, Büttner, Kathrin, Schoen, Andreas, Widera, Marek, Ciesek, Sandra, Weber, Friedemann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802332/
https://www.ncbi.nlm.nih.gov/pubmed/36713328
http://dx.doi.org/10.1093/pnasnexus/pgac067
Descripción
Sumario:The new variant of concern (VOC) of SARS-CoV-2, Omicron (B.1.1.529), is genetically very different from other VOCs. We compared Omicron with the preceding VOC Delta (B.1.617.2) and the wildtype (wt) strain (B.1) with respect to their interactions with the antiviral interferon (IFN-alpha/beta) response in infected cells. Our data indicate that IFN induction by Omicron is low and comparable to the wt, whereas Delta showed an increased IFN induction. However, Omicron exceeded both the wt and the Delta strain with respect to the ability to withstand the antiviral state imposed by IFN-alpha.

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