Omicron variant of SARS-CoV-2 exhibits an increased resilience to the antiviral type I interferon response

The new variant of concern (VOC) of SARS-CoV-2, Omicron (B.1.1.529), is genetically very different from other VOCs. We compared Omicron with the preceding VOC Delta (B.1.617.2) and the wildtype (wt) strain (B.1) with respect to their interactions with the antiviral interferon (IFN-alpha/beta) respon...

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Autores principales: Shalamova, Lyudmila, Felgenhauer, Ulrike, Wilhelm, Jochen, Schaubmar, Andreas R, Büttner, Kathrin, Schoen, Andreas, Widera, Marek, Ciesek, Sandra, Weber, Friedemann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802332/
https://www.ncbi.nlm.nih.gov/pubmed/36713328
http://dx.doi.org/10.1093/pnasnexus/pgac067
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author Shalamova, Lyudmila
Felgenhauer, Ulrike
Wilhelm, Jochen
Schaubmar, Andreas R
Büttner, Kathrin
Schoen, Andreas
Widera, Marek
Ciesek, Sandra
Weber, Friedemann
author_facet Shalamova, Lyudmila
Felgenhauer, Ulrike
Wilhelm, Jochen
Schaubmar, Andreas R
Büttner, Kathrin
Schoen, Andreas
Widera, Marek
Ciesek, Sandra
Weber, Friedemann
author_sort Shalamova, Lyudmila
collection PubMed
description The new variant of concern (VOC) of SARS-CoV-2, Omicron (B.1.1.529), is genetically very different from other VOCs. We compared Omicron with the preceding VOC Delta (B.1.617.2) and the wildtype (wt) strain (B.1) with respect to their interactions with the antiviral interferon (IFN-alpha/beta) response in infected cells. Our data indicate that IFN induction by Omicron is low and comparable to the wt, whereas Delta showed an increased IFN induction. However, Omicron exceeded both the wt and the Delta strain with respect to the ability to withstand the antiviral state imposed by IFN-alpha.
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spelling pubmed-98023322023-01-26 Omicron variant of SARS-CoV-2 exhibits an increased resilience to the antiviral type I interferon response Shalamova, Lyudmila Felgenhauer, Ulrike Wilhelm, Jochen Schaubmar, Andreas R Büttner, Kathrin Schoen, Andreas Widera, Marek Ciesek, Sandra Weber, Friedemann PNAS Nexus Brief Report The new variant of concern (VOC) of SARS-CoV-2, Omicron (B.1.1.529), is genetically very different from other VOCs. We compared Omicron with the preceding VOC Delta (B.1.617.2) and the wildtype (wt) strain (B.1) with respect to their interactions with the antiviral interferon (IFN-alpha/beta) response in infected cells. Our data indicate that IFN induction by Omicron is low and comparable to the wt, whereas Delta showed an increased IFN induction. However, Omicron exceeded both the wt and the Delta strain with respect to the ability to withstand the antiviral state imposed by IFN-alpha. Oxford University Press 2022-05-23 /pmc/articles/PMC9802332/ /pubmed/36713328 http://dx.doi.org/10.1093/pnasnexus/pgac067 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the National Academy of Sciences. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Shalamova, Lyudmila
Felgenhauer, Ulrike
Wilhelm, Jochen
Schaubmar, Andreas R
Büttner, Kathrin
Schoen, Andreas
Widera, Marek
Ciesek, Sandra
Weber, Friedemann
Omicron variant of SARS-CoV-2 exhibits an increased resilience to the antiviral type I interferon response
title Omicron variant of SARS-CoV-2 exhibits an increased resilience to the antiviral type I interferon response
title_full Omicron variant of SARS-CoV-2 exhibits an increased resilience to the antiviral type I interferon response
title_fullStr Omicron variant of SARS-CoV-2 exhibits an increased resilience to the antiviral type I interferon response
title_full_unstemmed Omicron variant of SARS-CoV-2 exhibits an increased resilience to the antiviral type I interferon response
title_short Omicron variant of SARS-CoV-2 exhibits an increased resilience to the antiviral type I interferon response
title_sort omicron variant of sars-cov-2 exhibits an increased resilience to the antiviral type i interferon response
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802332/
https://www.ncbi.nlm.nih.gov/pubmed/36713328
http://dx.doi.org/10.1093/pnasnexus/pgac067
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