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Second hit impels oncogenesis of retinoblastoma in patient-induced pluripotent stem cell-derived retinal organoids: direct evidence for Knudson's theory
Retinoblastoma (Rb) is a type of malignant tumor due to abnormal retinogenesis with biallelic mutations of the RB1 gene. Its pathogenesis has been proposed as a “two-mutation hypothesis” by Knudson since 1971; however, there remain some debates on disease onset sufficiency of the biallelic RB1 mutat...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802398/ https://www.ncbi.nlm.nih.gov/pubmed/36714839 http://dx.doi.org/10.1093/pnasnexus/pgac162 |