Cargando…
Development of a New Index to Assess Small Bowel Inflammation Severity in Crohn’s Disease Using Magnetic Resonance Enterography
BACKGROUND: The severity of small bowel (SB) inflammation in Crohn’s disease (CD) patients is a key component of the therapeutic choice. We aimed to develop a SB-CD Magnetic Resonance Enterography (MRE) index of Inflammation Severity (CDMRIS). METHODS: Each gastroenterologist/radiologist pair in 13...
Autores principales: | , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802414/ https://www.ncbi.nlm.nih.gov/pubmed/36777552 http://dx.doi.org/10.1093/crocol/otac004 |
_version_ | 1784861676942655488 |
---|---|
author | Bouhnik, Yoram Le Berre, Catherine Zappa, Magaly Lewin, Maïté Boudiaf, Mourad Zagdanski, Anne Marie Frampas, Eric Oudjit, Ammar Scotto, Béatrice Tissier, Muriel Annet, Laurence Aufort, Sophie Yzet, Thierry Cuilleron, Muriel Baudin, Guillaume Abitbol, Vered Cosnes, Jacques Bourreille, Arnaud Mary, Jean Yves |
author_facet | Bouhnik, Yoram Le Berre, Catherine Zappa, Magaly Lewin, Maïté Boudiaf, Mourad Zagdanski, Anne Marie Frampas, Eric Oudjit, Ammar Scotto, Béatrice Tissier, Muriel Annet, Laurence Aufort, Sophie Yzet, Thierry Cuilleron, Muriel Baudin, Guillaume Abitbol, Vered Cosnes, Jacques Bourreille, Arnaud Mary, Jean Yves |
author_sort | Bouhnik, Yoram |
collection | PubMed |
description | BACKGROUND: The severity of small bowel (SB) inflammation in Crohn’s disease (CD) patients is a key component of the therapeutic choice. We aimed to develop a SB-CD Magnetic Resonance Enterography (MRE) index of Inflammation Severity (CDMRIS). METHODS: Each gastroenterologist/radiologist pair in 13 centers selected MREs from 6 patients with SB-CD stratified on their perceived MRE inflammation severity. The 78 blinded MREs were allocated through balanced incomplete block design per severity stratum to these 13 pairs for rating the presence/severity of 13 preselected items for each SB 20-cm diseased segment. Global inflammation severity was evaluated using a 100-cm visual analog scale. Reproducibility of recorded items was evaluated. The CDMRIS was determined through linear mixed modeling as a combination of the numbers of segments with lesions highly correlated to global inflammation severity. RESULTS: Four hundred and forty-two readings were available. Global inflammation severity mean ± SD was 21.0 ± 16.2. The independent predictors explaining 54% of the global inflammation severity variance were the numbers of segments with T1 mild–moderate and severe intensity of enhancement, deep ulceration without fistula, comb sign, fistula, and abscess. Unbiased correlation between CDMRIS and global inflammation severity was 0.76. CONCLUSIONS: The CDMRIS is now available to evaluate the severity of SB-CD inflammation. External validation and sensitivity-to-change are mandatory next steps. |
format | Online Article Text |
id | pubmed-9802414 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-98024142023-02-10 Development of a New Index to Assess Small Bowel Inflammation Severity in Crohn’s Disease Using Magnetic Resonance Enterography Bouhnik, Yoram Le Berre, Catherine Zappa, Magaly Lewin, Maïté Boudiaf, Mourad Zagdanski, Anne Marie Frampas, Eric Oudjit, Ammar Scotto, Béatrice Tissier, Muriel Annet, Laurence Aufort, Sophie Yzet, Thierry Cuilleron, Muriel Baudin, Guillaume Abitbol, Vered Cosnes, Jacques Bourreille, Arnaud Mary, Jean Yves Crohns Colitis 360 Observations and Research BACKGROUND: The severity of small bowel (SB) inflammation in Crohn’s disease (CD) patients is a key component of the therapeutic choice. We aimed to develop a SB-CD Magnetic Resonance Enterography (MRE) index of Inflammation Severity (CDMRIS). METHODS: Each gastroenterologist/radiologist pair in 13 centers selected MREs from 6 patients with SB-CD stratified on their perceived MRE inflammation severity. The 78 blinded MREs were allocated through balanced incomplete block design per severity stratum to these 13 pairs for rating the presence/severity of 13 preselected items for each SB 20-cm diseased segment. Global inflammation severity was evaluated using a 100-cm visual analog scale. Reproducibility of recorded items was evaluated. The CDMRIS was determined through linear mixed modeling as a combination of the numbers of segments with lesions highly correlated to global inflammation severity. RESULTS: Four hundred and forty-two readings were available. Global inflammation severity mean ± SD was 21.0 ± 16.2. The independent predictors explaining 54% of the global inflammation severity variance were the numbers of segments with T1 mild–moderate and severe intensity of enhancement, deep ulceration without fistula, comb sign, fistula, and abscess. Unbiased correlation between CDMRIS and global inflammation severity was 0.76. CONCLUSIONS: The CDMRIS is now available to evaluate the severity of SB-CD inflammation. External validation and sensitivity-to-change are mandatory next steps. Oxford University Press 2022-02-05 /pmc/articles/PMC9802414/ /pubmed/36777552 http://dx.doi.org/10.1093/crocol/otac004 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Crohn's & Colitis Foundation. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Observations and Research Bouhnik, Yoram Le Berre, Catherine Zappa, Magaly Lewin, Maïté Boudiaf, Mourad Zagdanski, Anne Marie Frampas, Eric Oudjit, Ammar Scotto, Béatrice Tissier, Muriel Annet, Laurence Aufort, Sophie Yzet, Thierry Cuilleron, Muriel Baudin, Guillaume Abitbol, Vered Cosnes, Jacques Bourreille, Arnaud Mary, Jean Yves Development of a New Index to Assess Small Bowel Inflammation Severity in Crohn’s Disease Using Magnetic Resonance Enterography |
title | Development of a New Index to Assess Small Bowel Inflammation Severity in Crohn’s Disease Using Magnetic Resonance Enterography |
title_full | Development of a New Index to Assess Small Bowel Inflammation Severity in Crohn’s Disease Using Magnetic Resonance Enterography |
title_fullStr | Development of a New Index to Assess Small Bowel Inflammation Severity in Crohn’s Disease Using Magnetic Resonance Enterography |
title_full_unstemmed | Development of a New Index to Assess Small Bowel Inflammation Severity in Crohn’s Disease Using Magnetic Resonance Enterography |
title_short | Development of a New Index to Assess Small Bowel Inflammation Severity in Crohn’s Disease Using Magnetic Resonance Enterography |
title_sort | development of a new index to assess small bowel inflammation severity in crohn’s disease using magnetic resonance enterography |
topic | Observations and Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802414/ https://www.ncbi.nlm.nih.gov/pubmed/36777552 http://dx.doi.org/10.1093/crocol/otac004 |
work_keys_str_mv | AT bouhnikyoram developmentofanewindextoassesssmallbowelinflammationseverityincrohnsdiseaseusingmagneticresonanceenterography AT leberrecatherine developmentofanewindextoassesssmallbowelinflammationseverityincrohnsdiseaseusingmagneticresonanceenterography AT zappamagaly developmentofanewindextoassesssmallbowelinflammationseverityincrohnsdiseaseusingmagneticresonanceenterography AT lewinmaite developmentofanewindextoassesssmallbowelinflammationseverityincrohnsdiseaseusingmagneticresonanceenterography AT boudiafmourad developmentofanewindextoassesssmallbowelinflammationseverityincrohnsdiseaseusingmagneticresonanceenterography AT zagdanskiannemarie developmentofanewindextoassesssmallbowelinflammationseverityincrohnsdiseaseusingmagneticresonanceenterography AT frampaseric developmentofanewindextoassesssmallbowelinflammationseverityincrohnsdiseaseusingmagneticresonanceenterography AT oudjitammar developmentofanewindextoassesssmallbowelinflammationseverityincrohnsdiseaseusingmagneticresonanceenterography AT scottobeatrice developmentofanewindextoassesssmallbowelinflammationseverityincrohnsdiseaseusingmagneticresonanceenterography AT tissiermuriel developmentofanewindextoassesssmallbowelinflammationseverityincrohnsdiseaseusingmagneticresonanceenterography AT annetlaurence developmentofanewindextoassesssmallbowelinflammationseverityincrohnsdiseaseusingmagneticresonanceenterography AT aufortsophie developmentofanewindextoassesssmallbowelinflammationseverityincrohnsdiseaseusingmagneticresonanceenterography AT yzetthierry developmentofanewindextoassesssmallbowelinflammationseverityincrohnsdiseaseusingmagneticresonanceenterography AT cuilleronmuriel developmentofanewindextoassesssmallbowelinflammationseverityincrohnsdiseaseusingmagneticresonanceenterography AT baudinguillaume developmentofanewindextoassesssmallbowelinflammationseverityincrohnsdiseaseusingmagneticresonanceenterography AT abitbolvered developmentofanewindextoassesssmallbowelinflammationseverityincrohnsdiseaseusingmagneticresonanceenterography AT cosnesjacques developmentofanewindextoassesssmallbowelinflammationseverityincrohnsdiseaseusingmagneticresonanceenterography AT bourreillearnaud developmentofanewindextoassesssmallbowelinflammationseverityincrohnsdiseaseusingmagneticresonanceenterography AT maryjeanyves developmentofanewindextoassesssmallbowelinflammationseverityincrohnsdiseaseusingmagneticresonanceenterography AT developmentofanewindextoassesssmallbowelinflammationseverityincrohnsdiseaseusingmagneticresonanceenterography |