The Clinical Characteristics and Treatment Outcomes of Concomitant Eosinophilic Esophagitis and Inflammatory Bowel Disease

BACKGROUND: The clinical characteristics and treatment outcomes in patients with eosinophilic esophagitis (EoE) and inflammatory bowel disease (IBD) have not been extensively investigated. METHODS: We determined treatment outcomes and frequencies of disease-related complications in patients with EoE...

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Autores principales: Urquhart, Siri A, Quinn, Kevin P, Ravi, Karthik, Loftus, Edward V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Observations and Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802462/
https://www.ncbi.nlm.nih.gov/pubmed/36778939
http://dx.doi.org/10.1093/crocol/otab018
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author Urquhart, Siri A
Quinn, Kevin P
Ravi, Karthik
Loftus, Edward V
author_facet Urquhart, Siri A
Quinn, Kevin P
Ravi, Karthik
Loftus, Edward V
author_sort Urquhart, Siri A
collection PubMed
description BACKGROUND: The clinical characteristics and treatment outcomes in patients with eosinophilic esophagitis (EoE) and inflammatory bowel disease (IBD) have not been extensively investigated. METHODS: We determined treatment outcomes and frequencies of disease-related complications in patients with EoE and IBD. RESULTS: Among 69 patients who met inclusion criteria, 39 (56.5%) had a diagnosis of Crohn disease. Clinical and histologic response rates to proton pump inhibitors and topical steroids were 25.9% and 24.4%, respectively. CONCLUSIONS: Lower than expected clinical and histologic response rates for EoE suggest the combination of EoE and IBD is a medically refractory phenotype with more difficult to treat EoE.
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spelling pubmed-98024622023-02-10 The Clinical Characteristics and Treatment Outcomes of Concomitant Eosinophilic Esophagitis and Inflammatory Bowel Disease Urquhart, Siri A Quinn, Kevin P Ravi, Karthik Loftus, Edward V Crohns Colitis 360 Observations and Research BACKGROUND: The clinical characteristics and treatment outcomes in patients with eosinophilic esophagitis (EoE) and inflammatory bowel disease (IBD) have not been extensively investigated. METHODS: We determined treatment outcomes and frequencies of disease-related complications in patients with EoE and IBD. RESULTS: Among 69 patients who met inclusion criteria, 39 (56.5%) had a diagnosis of Crohn disease. Clinical and histologic response rates to proton pump inhibitors and topical steroids were 25.9% and 24.4%, respectively. CONCLUSIONS: Lower than expected clinical and histologic response rates for EoE suggest the combination of EoE and IBD is a medically refractory phenotype with more difficult to treat EoE. Oxford University Press 2021-05-12 /pmc/articles/PMC9802462/ /pubmed/36778939 http://dx.doi.org/10.1093/crocol/otab018 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of Crohn's & Colitis Foundation. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Observations and Research
Urquhart, Siri A
Quinn, Kevin P
Ravi, Karthik
Loftus, Edward V
The Clinical Characteristics and Treatment Outcomes of Concomitant Eosinophilic Esophagitis and Inflammatory Bowel Disease
title The Clinical Characteristics and Treatment Outcomes of Concomitant Eosinophilic Esophagitis and Inflammatory Bowel Disease
title_full The Clinical Characteristics and Treatment Outcomes of Concomitant Eosinophilic Esophagitis and Inflammatory Bowel Disease
title_fullStr The Clinical Characteristics and Treatment Outcomes of Concomitant Eosinophilic Esophagitis and Inflammatory Bowel Disease
title_full_unstemmed The Clinical Characteristics and Treatment Outcomes of Concomitant Eosinophilic Esophagitis and Inflammatory Bowel Disease
title_short The Clinical Characteristics and Treatment Outcomes of Concomitant Eosinophilic Esophagitis and Inflammatory Bowel Disease
title_sort clinical characteristics and treatment outcomes of concomitant eosinophilic esophagitis and inflammatory bowel disease
topic Observations and Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802462/
https://www.ncbi.nlm.nih.gov/pubmed/36778939
http://dx.doi.org/10.1093/crocol/otab018
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