Mass-selective and ice-free electron cryomicroscopy protein sample preparation via native electrospray ion-beam deposition

Despite tremendous advances in sample preparation and classification algorithms for electron cryomicroscopy (cryo-EM) and single-particle analysis (SPA), sample heterogeneity remains a major challenge and can prevent access to high-resolution structures. In addition, optimization of preparation cond...

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Detalles Bibliográficos
Autores principales: Esser, Tim K, Böhning, Jan, Fremdling, Paul, Agasid, Mark T, Costin, Adam, Fort, Kyle, Konijnenberg, Albert, Gilbert, Joshua D, Bahm, Alan, Makarov, Alexander, Robinson, Carol V, Benesch, Justin L P, Baker, Lindsay, Bharat, Tanmay A M, Gault, Joseph, Rauschenbach, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Physical Sciences and Engineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802471/
https://www.ncbi.nlm.nih.gov/pubmed/36714824
http://dx.doi.org/10.1093/pnasnexus/pgac153

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