Cargando…

Sequence patterns and signatures: Computational and experimental discovery of amyloid-forming peptides

Screening amino acid sequence space via experiments to discover peptides that self-assemble into amyloid fibrils is challenging. We have developed a computational peptide assembly design (PepAD) algorithm that enables the discovery of amyloid-forming peptides. Discontinuous molecular dynamics (DMD)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xiao, Xingqing, Robang, Alicia S, Sarma, Sudeep, Le, Justin V, Helmicki, Michael E, Lambert, Matthew J, Guerrero-Ferreira, Ricardo, Arboleda-Echavarria, Johana, Paravastu, Anant K, Hall, Carol K
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Physical Sciences and Engineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802472/ https://www.ncbi.nlm.nih.gov/pubmed/36712347 http://dx.doi.org/10.1093/pnasnexus/pgac263

Ejemplares similares

Distinct neurotoxic TDP-43 fibril polymorphs are generated by heterotypic interactions with α-Synuclein
por: Dhakal, Shailendra, et al.
Publicado: (2022)

De novo design of peptides that coassemble into β sheet–based nanofibrils
por: Xiao, Xingqing, et al.
Publicado: (2021)

Thermochromic Behavior of Polydiacetylene Nanomaterials Driven by Charged Peptide Amphiphiles
por: Lim, Sujeung, et al.
Publicado: (2023)

A common pathway for detergent-assisted oligomerization of Aβ42
por: Muhammedkutty, Fidha Nazreen Kunnath, et al.
Publicado: (2023)

Oligomer Formation by Amyloid-β42 in a Membrane-Mimicking Environment in Alzheimer’s Disease
por: Rosenberry, Terrone L., et al.
Publicado: (2022)

Amino Acid Signature Enables Proteins to Recognize Modified tRNA
por: Spears, Jessica L., et al.
Publicado: (2014)

Design of 8-mer Peptides that Block Clostridioides difficile Toxin A in Intestinal Cells
por: Sarma, Sudeep, et al.
Publicado: (2023)

Design of 8-mer peptides that block Clostridioides difficile toxin A in intestinal cells
por: Sarma, Sudeep, et al.
Publicado: (2023)

Charge guides pathway selection in β-sheet fibrillizing peptide co-assembly
por: Seroski, Dillon T., et al.
Publicado: (2020)

Phase Separation Behavior of Mixed Lipid Systems at Neutral and Low pH: Coarse-Grained Simulations with DMD/LIME
por: Curtis, Emily M., et al.
Publicado: (2014)

Rational Design of Antigen Incorporation Into Subunit Vaccine Biomaterials Can Enhance Antigen-Specific Immune Responses
por: Tsoras, Alexandra N., et al.
Publicado: (2020)

Energy Landscapes and Heat Capacity Signatures for Monomers and Dimers of Amyloid-Forming Hexapeptides
por: Nicy, et al.
Publicado: (2023)

A Novel Ferroptosis-Related lncRNAs Signature Predicts Clinical Prognosis and Is Associated With Immune Landscape in Pancreatic Cancer
por: Ping, Haiqin, et al.
Publicado: (2022)

Transcriptional Signatures of Tau and Amyloid Neuropathology
por: Castanho, Isabel, et al.
Publicado: (2020)

The Amyloid Forming Peptides Islet Amyloid Polypeptide and Amyloid β Interact at the Molecular Level
por: Wang, Ye, et al.
Publicado: (2021)

Paraplegia of late onset in adolescents with healed childhood caries of dorsal spine: A cause of pressure on the cord and treatment
por: Paravastu, Rangachari
Publicado: (2008)

The discovery of the growth cone and its influence on the study of axon guidance
por: Tamariz, Elisa, et al.
Publicado: (2015)

Polyamino acids take amyloid form
por: LeBrasseur, Nicole
Publicado: (2002)

On the Waxy or Amyloid Form of Bright's Disease
por: Stewart, T. Grainger
Publicado: (1861)

Amyloid-β Forms Fibrils by Nucleated Conformational Conversion of Oligomers
por: Lee, Jiyong, et al.
Publicado: (2011)

On reliable discovery of molecular signatures
por: Nilsson, Roland, et al.
Publicado: (2009)

Simulations of Amyloid-Forming Peptides in the Crystal State
por: Hosseini, A. Najla, et al.
Publicado: (2023)

Ex vivo Detection of Amyloid-β in Naturally Formed Oral Biofilm
por: Kanagasingam, Shalini, et al.
Publicado: (2022)

Transthyretin amyloid cardiomyopathy: An uncharted territory awaiting discovery
por: Porcari, Aldostefano, et al.
Publicado: (2020)

The hydrophobic effect characterises the thermodynamic signature of amyloid fibril growth
por: van Gils, Juami Hermine Mariama, et al.
Publicado: (2020)

Effects of Macromolecular Crowding on Amyloid Beta (16–22) Aggregation Using Coarse-Grained Simulations
por: Latshaw, David C., et al.
Publicado: (2014)

Comprehensive DNA Signature Discovery and Validation
por: Phillippy, Adam M, et al.
Publicado: (2007)

Smooth muscle titin forms in vitro amyloid aggregates
por: Bobylev, Alexandr G., et al.
Publicado: (2016)

Further Observations on the Waxy or Amyloid Form of Bright's Disease
por: Stewart, T. Grainger
Publicado: (1864)

Different Synergy in Amyloids and Biologically Active Forms of Proteins
por: Fabian, Piotr, et al.
Publicado: (2019)

The broad‐spectrum antibiofilm activity of amyloid‐forming hexapeptides
por: Chen, Dongru, et al.
Publicado: (2020)

Structural Specificity of Polymorphic Forms of α-Synuclein Amyloid
por: Roterman, Irena, et al.
Publicado: (2023)

Secondary Structure in Amyloids in Relation to Their Wild Type Forms
por: Roterman, Irena, et al.
Publicado: (2022)

Distinct thermodynamic signature of oligomer generation in the aggregation of the amyloid-β peptide
por: Cohen, Samuel I. A., et al.
Publicado: (2018)

Origins and Evolution of the HET-s Prion-Forming Protein: Searching for Other Amyloid-Forming Solenoids
por: Gendoo, Deena M. A., et al.
Publicado: (2011)

Yeast Models for Amyloids and Prions: Environmental Modulation and Drug Discovery
por: Chernova, Tatiana A., et al.
Publicado: (2019)

Desmin forms toxic, seeding-competent amyloid aggregates that persist in muscle fibers
por: Kedia, Niraja, et al.
Publicado: (2019)

Myosin Binding Protein-C Forms Amyloid-Like Aggregates In Vitro
por: Bobyleva, Liya G., et al.
Publicado: (2021)

Maximizing biomarker discovery by minimizing gene signatures
por: Chang, Chang, et al.
Publicado: (2011)

Discovery and Features of an Alkylating Signature in Colorectal Cancer
por: Gurjao, Carino, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_o22njtn8gtv5h24d86tuj8dij8