Utility of serum homocysteine in oral squamous cell carcinoma patients as a potential biomarker

BACKGROUND: In India, Oral cancer is one of the most common cancers. Despite advances in treatments, prognosis for oral cancer has remained poor with a five-year survival rate of 40–50%. Therefore, it is necessary to develop effective diagnostic methods for early diagnosis and better prognosis. Homo...

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Detalles Bibliográficos
Autores principales: Palaskar, Sangeeta, Joshi, Kalpana, Mukkanwar, Rutuja, Pawar, Rasika, Kulkarni, Gayatri, Pawar, Saurabhachandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802518/
https://www.ncbi.nlm.nih.gov/pubmed/36588856
http://dx.doi.org/10.4103/jomfp.jomfp_268_22
Descripción
Sumario:BACKGROUND: In India, Oral cancer is one of the most common cancers. Despite advances in treatments, prognosis for oral cancer has remained poor with a five-year survival rate of 40–50%. Therefore, it is necessary to develop effective diagnostic methods for early diagnosis and better prognosis. Homocysteine (Hcy) has been reported as a 'tumour marker' in various cancers such as breast cancer, colorectal cancer, lung cancer, cervical cancer. AIM: To study the levels of serum Hcy in oral squamous cell carcinoma (OSCC) patients. OBJECTIVES: To assess the clinical utility of serum Hcy as a potential tumour marker for OSCC cases. METHODOLOGY: Serum Hcy levels were studied and compared between patients with OSCC and healthy individuals. RESULTS: Serum Hcy levels were higher in patients having OSCC. CONCLUSION: Serum Hcy levels could be utilized as a biological marker in the diagnosis and the prognosis of OSCC patients.

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