Utility of serum homocysteine in oral squamous cell carcinoma patients as a potential biomarker

BACKGROUND: In India, Oral cancer is one of the most common cancers. Despite advances in treatments, prognosis for oral cancer has remained poor with a five-year survival rate of 40–50%. Therefore, it is necessary to develop effective diagnostic methods for early diagnosis and better prognosis. Homo...

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Autores principales: Palaskar, Sangeeta, Joshi, Kalpana, Mukkanwar, Rutuja, Pawar, Rasika, Kulkarni, Gayatri, Pawar, Saurabhachandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802518/
https://www.ncbi.nlm.nih.gov/pubmed/36588856
http://dx.doi.org/10.4103/jomfp.jomfp_268_22
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author Palaskar, Sangeeta
Joshi, Kalpana
Mukkanwar, Rutuja
Pawar, Rasika
Kulkarni, Gayatri
Pawar, Saurabhachandra
author_facet Palaskar, Sangeeta
Joshi, Kalpana
Mukkanwar, Rutuja
Pawar, Rasika
Kulkarni, Gayatri
Pawar, Saurabhachandra
author_sort Palaskar, Sangeeta
collection PubMed
description BACKGROUND: In India, Oral cancer is one of the most common cancers. Despite advances in treatments, prognosis for oral cancer has remained poor with a five-year survival rate of 40–50%. Therefore, it is necessary to develop effective diagnostic methods for early diagnosis and better prognosis. Homocysteine (Hcy) has been reported as a 'tumour marker' in various cancers such as breast cancer, colorectal cancer, lung cancer, cervical cancer. AIM: To study the levels of serum Hcy in oral squamous cell carcinoma (OSCC) patients. OBJECTIVES: To assess the clinical utility of serum Hcy as a potential tumour marker for OSCC cases. METHODOLOGY: Serum Hcy levels were studied and compared between patients with OSCC and healthy individuals. RESULTS: Serum Hcy levels were higher in patients having OSCC. CONCLUSION: Serum Hcy levels could be utilized as a biological marker in the diagnosis and the prognosis of OSCC patients.
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spelling pubmed-98025182022-12-31 Utility of serum homocysteine in oral squamous cell carcinoma patients as a potential biomarker Palaskar, Sangeeta Joshi, Kalpana Mukkanwar, Rutuja Pawar, Rasika Kulkarni, Gayatri Pawar, Saurabhachandra J Oral Maxillofac Pathol Original Article BACKGROUND: In India, Oral cancer is one of the most common cancers. Despite advances in treatments, prognosis for oral cancer has remained poor with a five-year survival rate of 40–50%. Therefore, it is necessary to develop effective diagnostic methods for early diagnosis and better prognosis. Homocysteine (Hcy) has been reported as a 'tumour marker' in various cancers such as breast cancer, colorectal cancer, lung cancer, cervical cancer. AIM: To study the levels of serum Hcy in oral squamous cell carcinoma (OSCC) patients. OBJECTIVES: To assess the clinical utility of serum Hcy as a potential tumour marker for OSCC cases. METHODOLOGY: Serum Hcy levels were studied and compared between patients with OSCC and healthy individuals. RESULTS: Serum Hcy levels were higher in patients having OSCC. CONCLUSION: Serum Hcy levels could be utilized as a biological marker in the diagnosis and the prognosis of OSCC patients. Wolters Kluwer - Medknow 2022 2022-10-17 /pmc/articles/PMC9802518/ /pubmed/36588856 http://dx.doi.org/10.4103/jomfp.jomfp_268_22 Text en Copyright: © 2022 Journal of Oral and Maxillofacial Pathology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Palaskar, Sangeeta
Joshi, Kalpana
Mukkanwar, Rutuja
Pawar, Rasika
Kulkarni, Gayatri
Pawar, Saurabhachandra
Utility of serum homocysteine in oral squamous cell carcinoma patients as a potential biomarker
title Utility of serum homocysteine in oral squamous cell carcinoma patients as a potential biomarker
title_full Utility of serum homocysteine in oral squamous cell carcinoma patients as a potential biomarker
title_fullStr Utility of serum homocysteine in oral squamous cell carcinoma patients as a potential biomarker
title_full_unstemmed Utility of serum homocysteine in oral squamous cell carcinoma patients as a potential biomarker
title_short Utility of serum homocysteine in oral squamous cell carcinoma patients as a potential biomarker
title_sort utility of serum homocysteine in oral squamous cell carcinoma patients as a potential biomarker
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802518/
https://www.ncbi.nlm.nih.gov/pubmed/36588856
http://dx.doi.org/10.4103/jomfp.jomfp_268_22
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