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Evaluation of p16 expression in oral and oropharyngeal squamous cell carcinoma

INTRODUCTION: Oral and oropharyngeal cancers together are the 6(th) most common cancers in the world and more than 90% are squamous cell carcinomas (OSCC, OPSCC). HPV is an important risk factor. p16 expression apart from indirectly assessing HPV infection, is an independent favorable prognostic mar...

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Autores principales: Saxena, Pallavi, Prasad, Sruthi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802529/
https://www.ncbi.nlm.nih.gov/pubmed/36588838
http://dx.doi.org/10.4103/jomfp.jomfp_278_22
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author Saxena, Pallavi
Prasad, Sruthi
author_facet Saxena, Pallavi
Prasad, Sruthi
author_sort Saxena, Pallavi
collection PubMed
description INTRODUCTION: Oral and oropharyngeal cancers together are the 6(th) most common cancers in the world and more than 90% are squamous cell carcinomas (OSCC, OPSCC). HPV is an important risk factor. p16 expression apart from indirectly assessing HPV infection, is an independent favorable prognostic marker. Lewis/Modified Lewis criteria of p16 grading identifies a subset of patients with improved overall survival. AIMS: (1) To evaluate p16 expression in these cancers. (2) To correlate p16 expression with age, gender, sub-site, histological type and grade. (3) To utilize the Lewis/modified Lewis criteria. METHODOLOGY: The study included 70 cases of OSSC's and OPSCC's. Histological features were analyzed. p16 expression was determined and graded. Results were analyzed and evaluated using Chi-square test (value of P < 0.05 was taken significant). RESULTS: p16 positivity was seen in 46/70 (66%) cases (44 OSCC & 26 OPSCC). It was more frequent in younger patients and significantly higher in males. There was no correlation between degree of differentiation and p16 expression. In OSCC, 72.7% were p16 positive, mostly from tongue, buccal mucosa, and hard palate. p16 positivity was seen in 53.8% of OPSCCs, mostly from base of tongue and tonsil. Also, 30.4% of all cases could be included in Lewis criteria and 39.1% in modified Lewis criteria. CONCLUSION: p16 is an inexpensive, easily available marker, it may be incorporated routinely in all histologically diagnosed cases of OSCC and OPSCC.
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spelling pubmed-98025292022-12-31 Evaluation of p16 expression in oral and oropharyngeal squamous cell carcinoma Saxena, Pallavi Prasad, Sruthi J Oral Maxillofac Pathol Original Article INTRODUCTION: Oral and oropharyngeal cancers together are the 6(th) most common cancers in the world and more than 90% are squamous cell carcinomas (OSCC, OPSCC). HPV is an important risk factor. p16 expression apart from indirectly assessing HPV infection, is an independent favorable prognostic marker. Lewis/Modified Lewis criteria of p16 grading identifies a subset of patients with improved overall survival. AIMS: (1) To evaluate p16 expression in these cancers. (2) To correlate p16 expression with age, gender, sub-site, histological type and grade. (3) To utilize the Lewis/modified Lewis criteria. METHODOLOGY: The study included 70 cases of OSSC's and OPSCC's. Histological features were analyzed. p16 expression was determined and graded. Results were analyzed and evaluated using Chi-square test (value of P < 0.05 was taken significant). RESULTS: p16 positivity was seen in 46/70 (66%) cases (44 OSCC & 26 OPSCC). It was more frequent in younger patients and significantly higher in males. There was no correlation between degree of differentiation and p16 expression. In OSCC, 72.7% were p16 positive, mostly from tongue, buccal mucosa, and hard palate. p16 positivity was seen in 53.8% of OPSCCs, mostly from base of tongue and tonsil. Also, 30.4% of all cases could be included in Lewis criteria and 39.1% in modified Lewis criteria. CONCLUSION: p16 is an inexpensive, easily available marker, it may be incorporated routinely in all histologically diagnosed cases of OSCC and OPSCC. Wolters Kluwer - Medknow 2022 2022-10-17 /pmc/articles/PMC9802529/ /pubmed/36588838 http://dx.doi.org/10.4103/jomfp.jomfp_278_22 Text en Copyright: © 2022 Journal of Oral and Maxillofacial Pathology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Saxena, Pallavi
Prasad, Sruthi
Evaluation of p16 expression in oral and oropharyngeal squamous cell carcinoma
title Evaluation of p16 expression in oral and oropharyngeal squamous cell carcinoma
title_full Evaluation of p16 expression in oral and oropharyngeal squamous cell carcinoma
title_fullStr Evaluation of p16 expression in oral and oropharyngeal squamous cell carcinoma
title_full_unstemmed Evaluation of p16 expression in oral and oropharyngeal squamous cell carcinoma
title_short Evaluation of p16 expression in oral and oropharyngeal squamous cell carcinoma
title_sort evaluation of p16 expression in oral and oropharyngeal squamous cell carcinoma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802529/
https://www.ncbi.nlm.nih.gov/pubmed/36588838
http://dx.doi.org/10.4103/jomfp.jomfp_278_22
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