Cargando…

Strategies to mitigate inflammation in management of complex congenital heart disease complicated by “multisystem inflammatory syndrome in children”

A 6-month-old boy, a case of Shone's complex, presented in decompensated state was found to have severe mitral stenosis along with multisystem inflammatory syndrome in children (MISC) warranting urgent surgical intervention. Various modalities including cytokine-adsorbing hemofilter were used t...

Descripción completa

Detalles Bibliográficos
Autores principales: Kumar, Anil, Joshi, Reena K., Aggarwal, Neeraj, Ray, Mily, Joshi, Raja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802620/
https://www.ncbi.nlm.nih.gov/pubmed/36589656
http://dx.doi.org/10.4103/apc.apc_16_22
Descripción
Sumario:A 6-month-old boy, a case of Shone's complex, presented in decompensated state was found to have severe mitral stenosis along with multisystem inflammatory syndrome in children (MISC) warranting urgent surgical intervention. Various modalities including cytokine-adsorbing hemofilter were used to target inflammation. Postoperatively, the child recovered from low cardiac output accompanied by decrease in the levels of inflammatory markers, inopressors, and ventilatory requirements. Open heart surgery in itself is a proinflammatory process and is best avoided during the active inflammatory phase of MISC. In the rare and unavoidable circumstance exemplified by this index case, multipronged strategy targeting inflammation as described can be successfully implemented.