Vaccination with SARS-CoV-2 spike protein lacking glycan shields elicits enhanced protective responses in animal models

A major challenge to end the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to develop a broadly protective vaccine that elicits long-term immunity. As the key immunogen, the viral surface spike (S) protein is frequently mutated, and conserved epitopes are shielde...

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Detalles Bibliográficos
Autores principales: Huang, Han-Yi, Liao, Hsin-Yu, Chen, Xiaorui, Wang, Szu-Wen, Cheng, Cheng-Wei, Shahed-Al-Mahmud, Md., Liu, Yo-Min, Mohapatra, Arpita, Chen, Ting-Hua, Lo, Jennifer M., Wu, Yi-Min, Ma, Hsiu-Hua, Chang, Yi-Hsuan, Tsai, Ho-Yang, Chou, Yu-Chi, Hsueh, Yi-Ping, Tsai, Ching-Yen, Huang, Pau-Yi, Chang, Sui-Yuan, Chao, Tai-Ling, Kao, Han-Chieh, Tsai, Ya-Min, Chen, Yen-Hui, Wu, Chung-Yi, Jan, Jia-Tsrong, Cheng, Ting-Jen Rachel, Lin, Kuo-I, Ma, Che, Wong, Chi-Huey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802656/
https://www.ncbi.nlm.nih.gov/pubmed/35230146
http://dx.doi.org/10.1126/scitranslmed.abm0899

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