Cargando…
The yeast molecular chaperone, Hsp104, influences transthyretin aggregate formation
Patients with the fatal disorder Transthyretin Amyloidosis (ATTR) experience polyneuropathy through the progressive destruction of peripheral nervous tissue. In these patients, the transthyretin (TTR) protein dissociates from its functional tetrameric structure, misfolds, and aggregates into extrace...
Autores principales: | Knier, Adam S., Davis, Emily E., Buchholz, Hannah E., Dorweiler, Jane E., Flannagan, Lauryn E., Manogaran, Anita L. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802906/ https://www.ncbi.nlm.nih.gov/pubmed/36590917 http://dx.doi.org/10.3389/fnmol.2022.1050472 |
Ejemplares similares
-
DMSO-mediated curing of several yeast prion variants involves Hsp104 expression and protein solubilization, and is decreased in several autophagy related gene (atg) mutants
por: Dorweiler, Jane E., et al.
Publicado: (2020) -
ATP hydrolysis by yeast Hsp104 determines protein aggregate dissolution and size in vivo
por: Sathyanarayanan, Udhayabhaskar, et al.
Publicado: (2020) -
Prion aggregate structure in yeast cells is determined by the Hsp104-Hsp110 disaggregase machinery
por: O’Driscoll, Jonathan, et al.
Publicado: (2015) -
Substrate Discrimination by ClpB and Hsp104
por: Johnston, Danielle M., et al.
Publicado: (2017) -
Hsp40s Specify Functions of Hsp104 and Hsp90 Protein Chaperone Machines
por: Reidy, Michael, et al.
Publicado: (2014)