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Association between myopia progression and quantity of laser treatment for retinopathy of prematurity

BACKGROUND: Previous studies found that infants with retinopathy of prematurity (ROP) who were treated for more posterior disease with a greater number of laser spots developed higher myopia. These studies included multiple physicians with variations in laser density. In treatments by a single physi...

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Autores principales: Hwang, Eileen S., Kassem, Iris S., Allozi, Rawan, Kravets, Sasha, Al-Kirwi, Khalid Y., Hallak, Joelle A., Costakos, Deborah M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9803142/
https://www.ncbi.nlm.nih.gov/pubmed/36584135
http://dx.doi.org/10.1371/journal.pone.0279898
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author Hwang, Eileen S.
Kassem, Iris S.
Allozi, Rawan
Kravets, Sasha
Al-Kirwi, Khalid Y.
Hallak, Joelle A.
Costakos, Deborah M.
author_facet Hwang, Eileen S.
Kassem, Iris S.
Allozi, Rawan
Kravets, Sasha
Al-Kirwi, Khalid Y.
Hallak, Joelle A.
Costakos, Deborah M.
author_sort Hwang, Eileen S.
collection PubMed
description BACKGROUND: Previous studies found that infants with retinopathy of prematurity (ROP) who were treated for more posterior disease with a greater number of laser spots developed higher myopia. These studies included multiple physicians with variations in laser density. In treatments by a single physician, laser spot count is a better surrogate for area of avascular retina and anterior-posterior location of disease, so that the relationship with myopia can be better assessed. METHODS: Our retrospective study included infants treated with laser for ROP by a single surgeon at a single center. Exclusion criteria were irregularities during laser and additional treatment for ROP. We assessed correlation between laser spot count and change in refractive error over time using a linear mixed effects model. RESULTS: We studied 153 eyes from 78 subjects treated with laser for ROP. The average gestational age at birth was 25.3±1.8 weeks, birth weight 737±248 grams, laser spot count 1793±728, and post-treatment follow up 37±29 months. Between corrected ages 0–1 years, the mean spherical equivalent was +0.4±2.3 diopters; between ages 1–2, it was -1.3±3.2D; and ages 2–3 was -0.8±3.1D. Eyes that received more laser spots had significantly greater change in refractive error over time (0.30D more myopia per year per 1000 spots). None of the eyes with hyperopia before 18 months developed myopia during the follow-up period. CONCLUSIONS: Greater myopia developed over time in infants with ROP treated by laser to a larger area of avascular retina.
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spelling pubmed-98031422022-12-31 Association between myopia progression and quantity of laser treatment for retinopathy of prematurity Hwang, Eileen S. Kassem, Iris S. Allozi, Rawan Kravets, Sasha Al-Kirwi, Khalid Y. Hallak, Joelle A. Costakos, Deborah M. PLoS One Research Article BACKGROUND: Previous studies found that infants with retinopathy of prematurity (ROP) who were treated for more posterior disease with a greater number of laser spots developed higher myopia. These studies included multiple physicians with variations in laser density. In treatments by a single physician, laser spot count is a better surrogate for area of avascular retina and anterior-posterior location of disease, so that the relationship with myopia can be better assessed. METHODS: Our retrospective study included infants treated with laser for ROP by a single surgeon at a single center. Exclusion criteria were irregularities during laser and additional treatment for ROP. We assessed correlation between laser spot count and change in refractive error over time using a linear mixed effects model. RESULTS: We studied 153 eyes from 78 subjects treated with laser for ROP. The average gestational age at birth was 25.3±1.8 weeks, birth weight 737±248 grams, laser spot count 1793±728, and post-treatment follow up 37±29 months. Between corrected ages 0–1 years, the mean spherical equivalent was +0.4±2.3 diopters; between ages 1–2, it was -1.3±3.2D; and ages 2–3 was -0.8±3.1D. Eyes that received more laser spots had significantly greater change in refractive error over time (0.30D more myopia per year per 1000 spots). None of the eyes with hyperopia before 18 months developed myopia during the follow-up period. CONCLUSIONS: Greater myopia developed over time in infants with ROP treated by laser to a larger area of avascular retina. Public Library of Science 2022-12-30 /pmc/articles/PMC9803142/ /pubmed/36584135 http://dx.doi.org/10.1371/journal.pone.0279898 Text en © 2022 Hwang et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Hwang, Eileen S.
Kassem, Iris S.
Allozi, Rawan
Kravets, Sasha
Al-Kirwi, Khalid Y.
Hallak, Joelle A.
Costakos, Deborah M.
Association between myopia progression and quantity of laser treatment for retinopathy of prematurity
title Association between myopia progression and quantity of laser treatment for retinopathy of prematurity
title_full Association between myopia progression and quantity of laser treatment for retinopathy of prematurity
title_fullStr Association between myopia progression and quantity of laser treatment for retinopathy of prematurity
title_full_unstemmed Association between myopia progression and quantity of laser treatment for retinopathy of prematurity
title_short Association between myopia progression and quantity of laser treatment for retinopathy of prematurity
title_sort association between myopia progression and quantity of laser treatment for retinopathy of prematurity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9803142/
https://www.ncbi.nlm.nih.gov/pubmed/36584135
http://dx.doi.org/10.1371/journal.pone.0279898
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