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Prevalence of pathogenic trypanosome species in naturally infected cattle of three sleeping sickness foci of the south of Chad

Although a diversity of trypanosome species have been detected in various animal taxa from human African trypanosomosis (HAT) foci, cattle trypanosomosis has not been addressed in HAT foci of west and central African countries including Chad. This study aimed to determine the prevalence of pathogeni...

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Autores principales: Vourchakbé, Joël, Tiofack, Arnol Auvaker Zebaze, Kante, Sartrien Tagueu, Barka, Padja Abdoul, Simo, Gustave
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9803169/
https://www.ncbi.nlm.nih.gov/pubmed/36584086
http://dx.doi.org/10.1371/journal.pone.0279730
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author Vourchakbé, Joël
Tiofack, Arnol Auvaker Zebaze
Kante, Sartrien Tagueu
Barka, Padja Abdoul
Simo, Gustave
author_facet Vourchakbé, Joël
Tiofack, Arnol Auvaker Zebaze
Kante, Sartrien Tagueu
Barka, Padja Abdoul
Simo, Gustave
author_sort Vourchakbé, Joël
collection PubMed
description Although a diversity of trypanosome species have been detected in various animal taxa from human African trypanosomosis (HAT) foci, cattle trypanosomosis has not been addressed in HAT foci of west and central African countries including Chad. This study aimed to determine the prevalence of pathogenic trypanosome species in cattle from three HAT foci of the south of Chad. Blood samples were collected from 1466 randomly selected cattle from HAT foci of Mandoul, Maro, and Moïssala in the south of Chad. For each animal, the sex, age and body condition were recorded. Rapid diagnostic test (RDT) was used to search Trypanosoma brucei gambiense antibodies while the capillary tube centrifugation (CTC) test and PCR-based methods enabled to detect and identify trypanosome species. From the 1466 cattle, 45 (3.1%) were positive to RDT. The prevalence of trypanosome infections revealed by CTC and PCR-based method were respectively 2.7% and 11.1%. Trypanosomes of the subgenus Trypanozoon were dominant (6.5%) followed by T. congolense savannah (2.9%), T. congolense forest (2.5%) and T. vivax (0.8%). No animal was found with DNA of human infective trypanosome (T. b. gambiense). The overall prevalence of trypanosome infections was significantly higher in animal from the Maro HAT focus (13.8%) than those from Mandoul (11.1%) and Moïssala HAT foci (8.0%). This prevalence was also significantly higher in animal having poor body condition (77.5%) than those with medium (11.2%) and good (0.5%) body condition. The overall prevalence of single and mixed infections were respectively 9.4% and 1.6%. This study revealed natural infections of several pathogenic trypanosome species in cattle from different HAT foci of Chad. It showed similar transmission patterns of these trypanosome species and highlighted the need of developing control strategies for animal African trypanosomosis (AAT) with the overarching goal of improving animal health and the economy of smallholder farmers.
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spelling pubmed-98031692022-12-31 Prevalence of pathogenic trypanosome species in naturally infected cattle of three sleeping sickness foci of the south of Chad Vourchakbé, Joël Tiofack, Arnol Auvaker Zebaze Kante, Sartrien Tagueu Barka, Padja Abdoul Simo, Gustave PLoS One Research Article Although a diversity of trypanosome species have been detected in various animal taxa from human African trypanosomosis (HAT) foci, cattle trypanosomosis has not been addressed in HAT foci of west and central African countries including Chad. This study aimed to determine the prevalence of pathogenic trypanosome species in cattle from three HAT foci of the south of Chad. Blood samples were collected from 1466 randomly selected cattle from HAT foci of Mandoul, Maro, and Moïssala in the south of Chad. For each animal, the sex, age and body condition were recorded. Rapid diagnostic test (RDT) was used to search Trypanosoma brucei gambiense antibodies while the capillary tube centrifugation (CTC) test and PCR-based methods enabled to detect and identify trypanosome species. From the 1466 cattle, 45 (3.1%) were positive to RDT. The prevalence of trypanosome infections revealed by CTC and PCR-based method were respectively 2.7% and 11.1%. Trypanosomes of the subgenus Trypanozoon were dominant (6.5%) followed by T. congolense savannah (2.9%), T. congolense forest (2.5%) and T. vivax (0.8%). No animal was found with DNA of human infective trypanosome (T. b. gambiense). The overall prevalence of trypanosome infections was significantly higher in animal from the Maro HAT focus (13.8%) than those from Mandoul (11.1%) and Moïssala HAT foci (8.0%). This prevalence was also significantly higher in animal having poor body condition (77.5%) than those with medium (11.2%) and good (0.5%) body condition. The overall prevalence of single and mixed infections were respectively 9.4% and 1.6%. This study revealed natural infections of several pathogenic trypanosome species in cattle from different HAT foci of Chad. It showed similar transmission patterns of these trypanosome species and highlighted the need of developing control strategies for animal African trypanosomosis (AAT) with the overarching goal of improving animal health and the economy of smallholder farmers. Public Library of Science 2022-12-30 /pmc/articles/PMC9803169/ /pubmed/36584086 http://dx.doi.org/10.1371/journal.pone.0279730 Text en © 2022 Vourchakbé et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Vourchakbé, Joël
Tiofack, Arnol Auvaker Zebaze
Kante, Sartrien Tagueu
Barka, Padja Abdoul
Simo, Gustave
Prevalence of pathogenic trypanosome species in naturally infected cattle of three sleeping sickness foci of the south of Chad
title Prevalence of pathogenic trypanosome species in naturally infected cattle of three sleeping sickness foci of the south of Chad
title_full Prevalence of pathogenic trypanosome species in naturally infected cattle of three sleeping sickness foci of the south of Chad
title_fullStr Prevalence of pathogenic trypanosome species in naturally infected cattle of three sleeping sickness foci of the south of Chad
title_full_unstemmed Prevalence of pathogenic trypanosome species in naturally infected cattle of three sleeping sickness foci of the south of Chad
title_short Prevalence of pathogenic trypanosome species in naturally infected cattle of three sleeping sickness foci of the south of Chad
title_sort prevalence of pathogenic trypanosome species in naturally infected cattle of three sleeping sickness foci of the south of chad
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9803169/
https://www.ncbi.nlm.nih.gov/pubmed/36584086
http://dx.doi.org/10.1371/journal.pone.0279730
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