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Risk factors for gallstone disease onset in Japan: Findings from the Shizuoka Study, a population-based cohort study

In the research literature on factors associated with gallstones, large population-based cohort studies are rare. We carried out a study of this type to explore risk factors for the onset of gallstones. This study included Japanese participants aged 40–107 years who were followed prospectively from...

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Autores principales: Higashizono, Kazuya, Nakatani, Eiji, Hawke, Philip, Fujimoto, Shuhei, Oba, Noriyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9803237/
https://www.ncbi.nlm.nih.gov/pubmed/36584097
http://dx.doi.org/10.1371/journal.pone.0274659
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author Higashizono, Kazuya
Nakatani, Eiji
Hawke, Philip
Fujimoto, Shuhei
Oba, Noriyuki
author_facet Higashizono, Kazuya
Nakatani, Eiji
Hawke, Philip
Fujimoto, Shuhei
Oba, Noriyuki
author_sort Higashizono, Kazuya
collection PubMed
description In the research literature on factors associated with gallstones, large population-based cohort studies are rare. We carried out a study of this type to explore risk factors for the onset of gallstones. This study included Japanese participants aged 40–107 years who were followed prospectively from January 2012 to September 2020 using a dataset composed of two individually linked databases, one containing annual health checkup records and the other containing medical claims for beneficiaries of the National Health Insurance System and the Medical Care System for Elderly in the Latter Stage of Life in Shizuoka Prefecture, Japan. Among the 611,930 participants in the analysis set, 23,843 (3.9%) were diagnosed with gallstones during the observational period (median [max]: 5.68 [7.5] years). Multivariate analysis revealed that risk of gallstone disease was increased by male sex, cerebrovascular disease, any malignancy, dementia, rheumatic disease, chronic pulmonary disease, hypertension, and H. pylori-infected gastritis. These findings provide essential insights into the etiology of cholelithiasis and may contribute to efforts to reduce the incidence of the disease.
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spelling pubmed-98032372022-12-31 Risk factors for gallstone disease onset in Japan: Findings from the Shizuoka Study, a population-based cohort study Higashizono, Kazuya Nakatani, Eiji Hawke, Philip Fujimoto, Shuhei Oba, Noriyuki PLoS One Research Article In the research literature on factors associated with gallstones, large population-based cohort studies are rare. We carried out a study of this type to explore risk factors for the onset of gallstones. This study included Japanese participants aged 40–107 years who were followed prospectively from January 2012 to September 2020 using a dataset composed of two individually linked databases, one containing annual health checkup records and the other containing medical claims for beneficiaries of the National Health Insurance System and the Medical Care System for Elderly in the Latter Stage of Life in Shizuoka Prefecture, Japan. Among the 611,930 participants in the analysis set, 23,843 (3.9%) were diagnosed with gallstones during the observational period (median [max]: 5.68 [7.5] years). Multivariate analysis revealed that risk of gallstone disease was increased by male sex, cerebrovascular disease, any malignancy, dementia, rheumatic disease, chronic pulmonary disease, hypertension, and H. pylori-infected gastritis. These findings provide essential insights into the etiology of cholelithiasis and may contribute to efforts to reduce the incidence of the disease. Public Library of Science 2022-12-30 /pmc/articles/PMC9803237/ /pubmed/36584097 http://dx.doi.org/10.1371/journal.pone.0274659 Text en © 2022 Higashizono et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Higashizono, Kazuya
Nakatani, Eiji
Hawke, Philip
Fujimoto, Shuhei
Oba, Noriyuki
Risk factors for gallstone disease onset in Japan: Findings from the Shizuoka Study, a population-based cohort study
title Risk factors for gallstone disease onset in Japan: Findings from the Shizuoka Study, a population-based cohort study
title_full Risk factors for gallstone disease onset in Japan: Findings from the Shizuoka Study, a population-based cohort study
title_fullStr Risk factors for gallstone disease onset in Japan: Findings from the Shizuoka Study, a population-based cohort study
title_full_unstemmed Risk factors for gallstone disease onset in Japan: Findings from the Shizuoka Study, a population-based cohort study
title_short Risk factors for gallstone disease onset in Japan: Findings from the Shizuoka Study, a population-based cohort study
title_sort risk factors for gallstone disease onset in japan: findings from the shizuoka study, a population-based cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9803237/
https://www.ncbi.nlm.nih.gov/pubmed/36584097
http://dx.doi.org/10.1371/journal.pone.0274659
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