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Calcium dependence of both lobes of calmodulin is involved in binding to a cytoplasmic domain of SK channels
KCa2.1–3 Ca(2+)-activated K(+)-channels (SK) require calmodulin to gate in response to cellular Ca(2+). A model for SK gating proposes that the N-terminal domain (N-lobe) of calmodulin is required for activation, but an immobile C-terminal domain (C-lobe) has constitutive, Ca(2+)-independent binding...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9803350/ https://www.ncbi.nlm.nih.gov/pubmed/36583726 http://dx.doi.org/10.7554/eLife.81303 |