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Unique crosstalk between platelet and leukocyte counts during treatment for acute coronary syndrome: A retrospective observational study

In the pathophysiology of acute coronary syndrome (ACS), platelet (PLT) and neutrophil (Neu) crosstalk may be important for activating coagulation and inflammation. It has been speculated that PLTs and Neu may affect each other’s cell counts; however, few studies have investigated this hypothesis. I...

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Autores principales: Shirasaki, Keisuke, Minai, Kosuke, Kawai, Makoto, Tanaka, Toshikazu D., Ogawa, Kazuo, Inoue, Yasunori, Morimoto, Satoshi, Nagoshi, Tomohisa, Ogawa, Takayuki, Komukai, Kimiaki, Yoshimura, Michihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9803419/
https://www.ncbi.nlm.nih.gov/pubmed/36595999
http://dx.doi.org/10.1097/MD.0000000000032439
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author Shirasaki, Keisuke
Minai, Kosuke
Kawai, Makoto
Tanaka, Toshikazu D.
Ogawa, Kazuo
Inoue, Yasunori
Morimoto, Satoshi
Nagoshi, Tomohisa
Ogawa, Takayuki
Komukai, Kimiaki
Yoshimura, Michihiro
author_facet Shirasaki, Keisuke
Minai, Kosuke
Kawai, Makoto
Tanaka, Toshikazu D.
Ogawa, Kazuo
Inoue, Yasunori
Morimoto, Satoshi
Nagoshi, Tomohisa
Ogawa, Takayuki
Komukai, Kimiaki
Yoshimura, Michihiro
author_sort Shirasaki, Keisuke
collection PubMed
description In the pathophysiology of acute coronary syndrome (ACS), platelet (PLT) and neutrophil (Neu) crosstalk may be important for activating coagulation and inflammation. It has been speculated that PLTs and Neu may affect each other’s cell counts; however, few studies have investigated this hypothesis. In this study, we measured changes in blood cell counts in 245 patients with ACS during treatment and investigated the mutual effects of each blood cell type. Path diagrams were drawn using structural equation modeling, and temporal changes in the count of each blood cell type and the relevance of these changes were analyzed. Throughout the treatment period, the numbers of all blood cell types (red blood cells [RBCs], leukocytes, and PLTs) were associated with each other before and after treatment. A detailed examination of the different cell types revealed that the PLT count at admission had a significant positive effect on the leukocyte (especially Neu) count after treatment. Conversely, the leukocyte (especially Neu) count at admission had a significant positive effect on the PLT count after treatment. During ACS, PLTs and leukocytes, especially Neu, stimulate each other to increase their numbers. The formation of a PLT-leukocyte complex may increase coagulation activity and inflammation, which can lead to a further increase in the counts of both blood cell types.
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spelling pubmed-98034192023-01-03 Unique crosstalk between platelet and leukocyte counts during treatment for acute coronary syndrome: A retrospective observational study Shirasaki, Keisuke Minai, Kosuke Kawai, Makoto Tanaka, Toshikazu D. Ogawa, Kazuo Inoue, Yasunori Morimoto, Satoshi Nagoshi, Tomohisa Ogawa, Takayuki Komukai, Kimiaki Yoshimura, Michihiro Medicine (Baltimore) 3400 In the pathophysiology of acute coronary syndrome (ACS), platelet (PLT) and neutrophil (Neu) crosstalk may be important for activating coagulation and inflammation. It has been speculated that PLTs and Neu may affect each other’s cell counts; however, few studies have investigated this hypothesis. In this study, we measured changes in blood cell counts in 245 patients with ACS during treatment and investigated the mutual effects of each blood cell type. Path diagrams were drawn using structural equation modeling, and temporal changes in the count of each blood cell type and the relevance of these changes were analyzed. Throughout the treatment period, the numbers of all blood cell types (red blood cells [RBCs], leukocytes, and PLTs) were associated with each other before and after treatment. A detailed examination of the different cell types revealed that the PLT count at admission had a significant positive effect on the leukocyte (especially Neu) count after treatment. Conversely, the leukocyte (especially Neu) count at admission had a significant positive effect on the PLT count after treatment. During ACS, PLTs and leukocytes, especially Neu, stimulate each other to increase their numbers. The formation of a PLT-leukocyte complex may increase coagulation activity and inflammation, which can lead to a further increase in the counts of both blood cell types. Lippincott Williams & Wilkins 2022-12-30 /pmc/articles/PMC9803419/ /pubmed/36595999 http://dx.doi.org/10.1097/MD.0000000000032439 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 3400
Shirasaki, Keisuke
Minai, Kosuke
Kawai, Makoto
Tanaka, Toshikazu D.
Ogawa, Kazuo
Inoue, Yasunori
Morimoto, Satoshi
Nagoshi, Tomohisa
Ogawa, Takayuki
Komukai, Kimiaki
Yoshimura, Michihiro
Unique crosstalk between platelet and leukocyte counts during treatment for acute coronary syndrome: A retrospective observational study
title Unique crosstalk between platelet and leukocyte counts during treatment for acute coronary syndrome: A retrospective observational study
title_full Unique crosstalk between platelet and leukocyte counts during treatment for acute coronary syndrome: A retrospective observational study
title_fullStr Unique crosstalk between platelet and leukocyte counts during treatment for acute coronary syndrome: A retrospective observational study
title_full_unstemmed Unique crosstalk between platelet and leukocyte counts during treatment for acute coronary syndrome: A retrospective observational study
title_short Unique crosstalk between platelet and leukocyte counts during treatment for acute coronary syndrome: A retrospective observational study
title_sort unique crosstalk between platelet and leukocyte counts during treatment for acute coronary syndrome: a retrospective observational study
topic 3400
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9803419/
https://www.ncbi.nlm.nih.gov/pubmed/36595999
http://dx.doi.org/10.1097/MD.0000000000032439
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