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The effect and safety of low-dose Tripterygium wilfordii in patients with type 2 diabetic nephropathy: A meta-analysis
This review aims to assess the efficacy and safety of low-dose Tripterygium wilfordii Hook F (TWHF) in treating type 2 diabetic nephropathy (DN) and provide high-level evidence supporting its normalized application. METHODS: Seven electronic databases were queried to locate trials that qualify. Rand...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9803423/ https://www.ncbi.nlm.nih.gov/pubmed/36596065 http://dx.doi.org/10.1097/MD.0000000000032504 |
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author | Chen, Yixuan Lu, Meiqi Feng, Yiting Gao, Qing |
author_facet | Chen, Yixuan Lu, Meiqi Feng, Yiting Gao, Qing |
author_sort | Chen, Yixuan |
collection | PubMed |
description | This review aims to assess the efficacy and safety of low-dose Tripterygium wilfordii Hook F (TWHF) in treating type 2 diabetic nephropathy (DN) and provide high-level evidence supporting its normalized application. METHODS: Seven electronic databases were queried to locate trials that qualify. Randomized controlled trials (RCTs) about low-dose TWHF long-term treatment of type 2 DN are included. After data extraction and quality evaluation of the clinical studies that met the inclusion criteria, a meta-analysis was performed using RevMan 5.4 and Stata 14. RESULTS: A total of 23 RCTs were included. For the patients in the trial group, the effective rate [confidence interval (CI), odd ratio] [odd ratio = 1.38, 95% CI (1.22–1.56), P < .001], albumin [standard mean difference (SMD) = 0.58, 95% CI (0.18–0.98), P = .004], 24-hour urine total protein [SMD = −1.329, 95% CI = (−1.647 to −1.012), P < .001], serum creatinine [SMD = −0.64, 95% CI = (−0.86 to −0.31), P < .001], and the untoward effect [RR = 2.43 95% CI = (1.23–4.82), P = .01] were significantly higher than those in the control group. However, in white blood cell [Weighted mean difference = −0.27, 95% CI (−0.54 to 0.01), P = .06] and blood urea nitrogen [Weighted mean difference = −0.11, 95% CI (−0.42 to 0.21), z = 0.67, P = .50], none of the differences were significant compared with the control group. CONCLUSION: This suggests that low-dose TWHF positively affects patients with type 2 DN after a long course of treatment. Although there are some side effects, symptoms can improve after medication suspension or symptomatic treatment. Limited by the methodological quality of the included studies, this conclusion needs to be verified by more large-sample RCTs with rigorous design and long-term follow-up. |
format | Online Article Text |
id | pubmed-9803423 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-98034232023-01-03 The effect and safety of low-dose Tripterygium wilfordii in patients with type 2 diabetic nephropathy: A meta-analysis Chen, Yixuan Lu, Meiqi Feng, Yiting Gao, Qing Medicine (Baltimore) 5200 This review aims to assess the efficacy and safety of low-dose Tripterygium wilfordii Hook F (TWHF) in treating type 2 diabetic nephropathy (DN) and provide high-level evidence supporting its normalized application. METHODS: Seven electronic databases were queried to locate trials that qualify. Randomized controlled trials (RCTs) about low-dose TWHF long-term treatment of type 2 DN are included. After data extraction and quality evaluation of the clinical studies that met the inclusion criteria, a meta-analysis was performed using RevMan 5.4 and Stata 14. RESULTS: A total of 23 RCTs were included. For the patients in the trial group, the effective rate [confidence interval (CI), odd ratio] [odd ratio = 1.38, 95% CI (1.22–1.56), P < .001], albumin [standard mean difference (SMD) = 0.58, 95% CI (0.18–0.98), P = .004], 24-hour urine total protein [SMD = −1.329, 95% CI = (−1.647 to −1.012), P < .001], serum creatinine [SMD = −0.64, 95% CI = (−0.86 to −0.31), P < .001], and the untoward effect [RR = 2.43 95% CI = (1.23–4.82), P = .01] were significantly higher than those in the control group. However, in white blood cell [Weighted mean difference = −0.27, 95% CI (−0.54 to 0.01), P = .06] and blood urea nitrogen [Weighted mean difference = −0.11, 95% CI (−0.42 to 0.21), z = 0.67, P = .50], none of the differences were significant compared with the control group. CONCLUSION: This suggests that low-dose TWHF positively affects patients with type 2 DN after a long course of treatment. Although there are some side effects, symptoms can improve after medication suspension or symptomatic treatment. Limited by the methodological quality of the included studies, this conclusion needs to be verified by more large-sample RCTs with rigorous design and long-term follow-up. Lippincott Williams & Wilkins 2022-12-30 /pmc/articles/PMC9803423/ /pubmed/36596065 http://dx.doi.org/10.1097/MD.0000000000032504 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. |
spellingShingle | 5200 Chen, Yixuan Lu, Meiqi Feng, Yiting Gao, Qing The effect and safety of low-dose Tripterygium wilfordii in patients with type 2 diabetic nephropathy: A meta-analysis |
title | The effect and safety of low-dose Tripterygium wilfordii in patients with type 2 diabetic nephropathy: A meta-analysis |
title_full | The effect and safety of low-dose Tripterygium wilfordii in patients with type 2 diabetic nephropathy: A meta-analysis |
title_fullStr | The effect and safety of low-dose Tripterygium wilfordii in patients with type 2 diabetic nephropathy: A meta-analysis |
title_full_unstemmed | The effect and safety of low-dose Tripterygium wilfordii in patients with type 2 diabetic nephropathy: A meta-analysis |
title_short | The effect and safety of low-dose Tripterygium wilfordii in patients with type 2 diabetic nephropathy: A meta-analysis |
title_sort | effect and safety of low-dose tripterygium wilfordii in patients with type 2 diabetic nephropathy: a meta-analysis |
topic | 5200 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9803423/ https://www.ncbi.nlm.nih.gov/pubmed/36596065 http://dx.doi.org/10.1097/MD.0000000000032504 |
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