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Effectiveness of combined pregabalin and celecoxib for treatment of acute postoperative pain: A meta-analysis and systematic review

To estimate the acute analgesic efficacy of combined Pregabalin and Celecoxib after operation via a systematic review and meta-analysis. METHODS: Studies for inclusion were randomized controlled trials, reporting on relevant outcomes (0–6 hours, 24 hours, 7 days pain scores) with treatment with comb...

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Autores principales: Ni, Jing-Mei, Zhu, Xuan, Wang, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9803517/
https://www.ncbi.nlm.nih.gov/pubmed/36596023
http://dx.doi.org/10.1097/MD.0000000000032080
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author Ni, Jing-Mei
Zhu, Xuan
Wang, Ping
author_facet Ni, Jing-Mei
Zhu, Xuan
Wang, Ping
author_sort Ni, Jing-Mei
collection PubMed
description To estimate the acute analgesic efficacy of combined Pregabalin and Celecoxib after operation via a systematic review and meta-analysis. METHODS: Studies for inclusion were randomized controlled trials, reporting on relevant outcomes (0–6 hours, 24 hours, 7 days pain scores) with treatment with combined Pregabalin and Celecoxib. RESULTS: The pooled results from meta-analysis demonstrated that compared with placebo, combined Pregabalin and Celecoxib reduced pain scores at 0 to 6 hours in 3 articles, 24 hours in 5 articles, 7 days in 2 articles (standard mean difference [SMD], −3.10 at 0–6 hours, −2.80 at 24 hours, −1.32 at 7 days, respectively). Combined Pregabalin and Celecoxib could significantly reduce the postoperative narcotic consumption in 3 studies (SMD, −1.99 at 36 hour). DISCUSSION: This work suggested that combined Pregabalin and Celecoxib were efficacious in reduction of postoperative pain and narcotic requirements after surgery, whereas more trials are needed to further identify the efficacy of combined Pregabalin and Celecoxib in the management of acute postoperative pain.
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spelling pubmed-98035172023-01-03 Effectiveness of combined pregabalin and celecoxib for treatment of acute postoperative pain: A meta-analysis and systematic review Ni, Jing-Mei Zhu, Xuan Wang, Ping Medicine (Baltimore) 3300 To estimate the acute analgesic efficacy of combined Pregabalin and Celecoxib after operation via a systematic review and meta-analysis. METHODS: Studies for inclusion were randomized controlled trials, reporting on relevant outcomes (0–6 hours, 24 hours, 7 days pain scores) with treatment with combined Pregabalin and Celecoxib. RESULTS: The pooled results from meta-analysis demonstrated that compared with placebo, combined Pregabalin and Celecoxib reduced pain scores at 0 to 6 hours in 3 articles, 24 hours in 5 articles, 7 days in 2 articles (standard mean difference [SMD], −3.10 at 0–6 hours, −2.80 at 24 hours, −1.32 at 7 days, respectively). Combined Pregabalin and Celecoxib could significantly reduce the postoperative narcotic consumption in 3 studies (SMD, −1.99 at 36 hour). DISCUSSION: This work suggested that combined Pregabalin and Celecoxib were efficacious in reduction of postoperative pain and narcotic requirements after surgery, whereas more trials are needed to further identify the efficacy of combined Pregabalin and Celecoxib in the management of acute postoperative pain. Lippincott Williams & Wilkins 2022-12-30 /pmc/articles/PMC9803517/ /pubmed/36596023 http://dx.doi.org/10.1097/MD.0000000000032080 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 3300
Ni, Jing-Mei
Zhu, Xuan
Wang, Ping
Effectiveness of combined pregabalin and celecoxib for treatment of acute postoperative pain: A meta-analysis and systematic review
title Effectiveness of combined pregabalin and celecoxib for treatment of acute postoperative pain: A meta-analysis and systematic review
title_full Effectiveness of combined pregabalin and celecoxib for treatment of acute postoperative pain: A meta-analysis and systematic review
title_fullStr Effectiveness of combined pregabalin and celecoxib for treatment of acute postoperative pain: A meta-analysis and systematic review
title_full_unstemmed Effectiveness of combined pregabalin and celecoxib for treatment of acute postoperative pain: A meta-analysis and systematic review
title_short Effectiveness of combined pregabalin and celecoxib for treatment of acute postoperative pain: A meta-analysis and systematic review
title_sort effectiveness of combined pregabalin and celecoxib for treatment of acute postoperative pain: a meta-analysis and systematic review
topic 3300
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9803517/
https://www.ncbi.nlm.nih.gov/pubmed/36596023
http://dx.doi.org/10.1097/MD.0000000000032080
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