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Post-traumatic brain injury glioma: Characteristics, report of 2 cases report and literature review

Traumatic brain injury (TBI) as a pathogenetic factor in glioma remains controversial, and currently there is still no clear mechanism behind post-TBI glioma. Thus, we provide two case reports of post-TBI glioma contributing power to this research, and we provide a summary of the mechanisms of post-...

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Autores principales: Chen, Kui, Andrade-Barazarte, Hugo, Liang, Wenjia, Zhu, Qingyun, Guo, Haixing, Li, Yanxin, Li, Haichun, Qian, Rongjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9803520/
https://www.ncbi.nlm.nih.gov/pubmed/36596004
http://dx.doi.org/10.1097/MD.0000000000032477
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author Chen, Kui
Andrade-Barazarte, Hugo
Liang, Wenjia
Zhu, Qingyun
Guo, Haixing
Li, Yanxin
Li, Haichun
Qian, Rongjun
author_facet Chen, Kui
Andrade-Barazarte, Hugo
Liang, Wenjia
Zhu, Qingyun
Guo, Haixing
Li, Yanxin
Li, Haichun
Qian, Rongjun
author_sort Chen, Kui
collection PubMed
description Traumatic brain injury (TBI) as a pathogenetic factor in glioma remains controversial, and currently there is still no clear mechanism behind post-TBI glioma. Thus, we provide two case reports of post-TBI glioma contributing power to this research, and we provide a summary of the mechanisms of post-TBI glioma through literature review. METHODS: We report two cases of brain gliomas that developed in the scar of a previous brain trauma. Both patients were male and both had suffered prior traumatic brain injuries (time interval 10–20 years), and postoperative pathological findings reported glioblastoma and WHO grade III glioma, respectively. RESULTS: These two cases further support the association of between traumatic brain injury and gliomas development. CONCLUSION: Although the epidemiological investigation between TBI and glioma is still controversial, there are still some important aspects here that can determine the possibility between TBI and gliomagenesis. Besides, we found that the reparative response of neural stem cells and the dysregulation of inflammatory cells are timportant theories of the mechanism of post-TBI glioma.
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spelling pubmed-98035202023-01-03 Post-traumatic brain injury glioma: Characteristics, report of 2 cases report and literature review Chen, Kui Andrade-Barazarte, Hugo Liang, Wenjia Zhu, Qingyun Guo, Haixing Li, Yanxin Li, Haichun Qian, Rongjun Medicine (Baltimore) 7100 Traumatic brain injury (TBI) as a pathogenetic factor in glioma remains controversial, and currently there is still no clear mechanism behind post-TBI glioma. Thus, we provide two case reports of post-TBI glioma contributing power to this research, and we provide a summary of the mechanisms of post-TBI glioma through literature review. METHODS: We report two cases of brain gliomas that developed in the scar of a previous brain trauma. Both patients were male and both had suffered prior traumatic brain injuries (time interval 10–20 years), and postoperative pathological findings reported glioblastoma and WHO grade III glioma, respectively. RESULTS: These two cases further support the association of between traumatic brain injury and gliomas development. CONCLUSION: Although the epidemiological investigation between TBI and glioma is still controversial, there are still some important aspects here that can determine the possibility between TBI and gliomagenesis. Besides, we found that the reparative response of neural stem cells and the dysregulation of inflammatory cells are timportant theories of the mechanism of post-TBI glioma. Lippincott Williams & Wilkins 2022-12-30 /pmc/articles/PMC9803520/ /pubmed/36596004 http://dx.doi.org/10.1097/MD.0000000000032477 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 7100
Chen, Kui
Andrade-Barazarte, Hugo
Liang, Wenjia
Zhu, Qingyun
Guo, Haixing
Li, Yanxin
Li, Haichun
Qian, Rongjun
Post-traumatic brain injury glioma: Characteristics, report of 2 cases report and literature review
title Post-traumatic brain injury glioma: Characteristics, report of 2 cases report and literature review
title_full Post-traumatic brain injury glioma: Characteristics, report of 2 cases report and literature review
title_fullStr Post-traumatic brain injury glioma: Characteristics, report of 2 cases report and literature review
title_full_unstemmed Post-traumatic brain injury glioma: Characteristics, report of 2 cases report and literature review
title_short Post-traumatic brain injury glioma: Characteristics, report of 2 cases report and literature review
title_sort post-traumatic brain injury glioma: characteristics, report of 2 cases report and literature review
topic 7100
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9803520/
https://www.ncbi.nlm.nih.gov/pubmed/36596004
http://dx.doi.org/10.1097/MD.0000000000032477
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