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An uncommon perineal embryonal rhabdomyosarcoma in adult: A case report

Embryonal rhabdomyosarcoma (ERMS) is a major subtype of rhabdomyosarcoma, mainly affect children. There is seldom report for perineal ERMS in adults, since its rare location and the age. PATIENT CONCERNS: A 20-year old male adult was admitted due to the perineal mass. DIAGNOSES: Diagnosis by histopa...

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Detalles Bibliográficos
Autores principales: Qu, Sifeng, Li, Weiwei, Yao, Yuan, Huang, Huangwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9803527/
https://www.ncbi.nlm.nih.gov/pubmed/36596039
http://dx.doi.org/10.1097/MD.0000000000032529
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author Qu, Sifeng
Li, Weiwei
Yao, Yuan
Huang, Huangwei
author_facet Qu, Sifeng
Li, Weiwei
Yao, Yuan
Huang, Huangwei
author_sort Qu, Sifeng
collection PubMed
description Embryonal rhabdomyosarcoma (ERMS) is a major subtype of rhabdomyosarcoma, mainly affect children. There is seldom report for perineal ERMS in adults, since its rare location and the age. PATIENT CONCERNS: A 20-year old male adult was admitted due to the perineal mass. DIAGNOSES: Diagnosis by histopathological examination of the biopsy sample was ERMS. Magnetic resonance imaging showed the tumor was found in the perineal region, with metastasis to pelvic cavity, right testis, lymph nodes and bone. INTERVENTIONS: The patient received Isophosphamide and Epirubicin for 4 cycles, followed by Irinotecan and Vindesine Sulfate for 2 cycles, then cisplatin, Dacarbazine and Apatinib for 3 cycles. OUTCOME: The patient showed no response to chemotherapy. LESSONS: Perineal ERMS in adults is very rare. There is still no standard therapy for adult ERMS. Personalized therapy might be promising treatment for each individual.
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spelling pubmed-98035272023-01-03 An uncommon perineal embryonal rhabdomyosarcoma in adult: A case report Qu, Sifeng Li, Weiwei Yao, Yuan Huang, Huangwei Medicine (Baltimore) 5700 Embryonal rhabdomyosarcoma (ERMS) is a major subtype of rhabdomyosarcoma, mainly affect children. There is seldom report for perineal ERMS in adults, since its rare location and the age. PATIENT CONCERNS: A 20-year old male adult was admitted due to the perineal mass. DIAGNOSES: Diagnosis by histopathological examination of the biopsy sample was ERMS. Magnetic resonance imaging showed the tumor was found in the perineal region, with metastasis to pelvic cavity, right testis, lymph nodes and bone. INTERVENTIONS: The patient received Isophosphamide and Epirubicin for 4 cycles, followed by Irinotecan and Vindesine Sulfate for 2 cycles, then cisplatin, Dacarbazine and Apatinib for 3 cycles. OUTCOME: The patient showed no response to chemotherapy. LESSONS: Perineal ERMS in adults is very rare. There is still no standard therapy for adult ERMS. Personalized therapy might be promising treatment for each individual. Lippincott Williams & Wilkins 2022-12-30 /pmc/articles/PMC9803527/ /pubmed/36596039 http://dx.doi.org/10.1097/MD.0000000000032529 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 5700
Qu, Sifeng
Li, Weiwei
Yao, Yuan
Huang, Huangwei
An uncommon perineal embryonal rhabdomyosarcoma in adult: A case report
title An uncommon perineal embryonal rhabdomyosarcoma in adult: A case report
title_full An uncommon perineal embryonal rhabdomyosarcoma in adult: A case report
title_fullStr An uncommon perineal embryonal rhabdomyosarcoma in adult: A case report
title_full_unstemmed An uncommon perineal embryonal rhabdomyosarcoma in adult: A case report
title_short An uncommon perineal embryonal rhabdomyosarcoma in adult: A case report
title_sort uncommon perineal embryonal rhabdomyosarcoma in adult: a case report
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9803527/
https://www.ncbi.nlm.nih.gov/pubmed/36596039
http://dx.doi.org/10.1097/MD.0000000000032529
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