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Comparison of Two Standard Treatment Approaches in Locoregionally Advanced Nasopharyngeal Carcinoma

Objectives  To compare outcomes and toxicity of two standard treatment approaches of advanced nasopharyngeal carcinoma (NPC). Methods  Between 2010 and 2016, patients with NPC, stage II–IVa, treated with induction chemotherapy (IC) (TPF), followed by concurrent chemoradiotherapy (CCRT) (induction gr...

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Autores principales: Mohamad, Issa, Abu-Hijleh, Fawzi, Mayta, Ebrahim, Abu-Hejleh, Taher, Al-Gargaz, Wisam, Al Mousa, Abdellatif, Abu-Hijlih, Ramiz, Hosni, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Medical and Scientific Publishers Pvt. Ltd. 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9803531/
https://www.ncbi.nlm.nih.gov/pubmed/36588606
http://dx.doi.org/10.1055/s-0042-1742724
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author Mohamad, Issa
Abu-Hijleh, Fawzi
Mayta, Ebrahim
Abu-Hejleh, Taher
Al-Gargaz, Wisam
Al Mousa, Abdellatif
Abu-Hijlih, Ramiz
Hosni, Ali
author_facet Mohamad, Issa
Abu-Hijleh, Fawzi
Mayta, Ebrahim
Abu-Hejleh, Taher
Al-Gargaz, Wisam
Al Mousa, Abdellatif
Abu-Hijlih, Ramiz
Hosni, Ali
author_sort Mohamad, Issa
collection PubMed
description Objectives  To compare outcomes and toxicity of two standard treatment approaches of advanced nasopharyngeal carcinoma (NPC). Methods  Between 2010 and 2016, patients with NPC, stage II–IVa, treated with induction chemotherapy (IC) (TPF), followed by concurrent chemoradiotherapy (CCRT) (induction group), or CCRT, followed by adjuvant chemotherapy (AC) (PF) (no-induction group), were retrospectively reviewed. CCRT included platinum-based chemotherapy with intensity-modulated radiotherapy. Survival outcomes, the pattern of failures, toxicity, and predictors for survival outcomes were evaluated. Results  A total of 110 patients were included, 65 in the induction group and 45 in the no-induction group. There were no significant differences in the DFS and overall survival (OS) at 3 years between the two groups. On multivariate analysis, performance status (1 vs. 0) predicted worse OS. The 3-year cumulative incidence rates for local, regional, and distant failures were 58.5% (95% confidence interval [CI]: 8.4–89%), 58.00% (95% CI: 8–88.8%), and 63.90% (95% CI: 14.1–90.2%), respectively. IC had more frequent acute grade (G) II anemia (13 vs. 1, p  < 0.01), late G II brain toxicity (4 vs. 1, p  < 0.01), and late G II dysphagia (32 vs. 11, p  = 0.01). Conclusions  Survival outcomes were comparable between the two groups. IC had more frequent acute G II anemia and late G II brain and esophageal toxicities.
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spelling pubmed-98035312022-12-31 Comparison of Two Standard Treatment Approaches in Locoregionally Advanced Nasopharyngeal Carcinoma Mohamad, Issa Abu-Hijleh, Fawzi Mayta, Ebrahim Abu-Hejleh, Taher Al-Gargaz, Wisam Al Mousa, Abdellatif Abu-Hijlih, Ramiz Hosni, Ali South Asian J Cancer Objectives  To compare outcomes and toxicity of two standard treatment approaches of advanced nasopharyngeal carcinoma (NPC). Methods  Between 2010 and 2016, patients with NPC, stage II–IVa, treated with induction chemotherapy (IC) (TPF), followed by concurrent chemoradiotherapy (CCRT) (induction group), or CCRT, followed by adjuvant chemotherapy (AC) (PF) (no-induction group), were retrospectively reviewed. CCRT included platinum-based chemotherapy with intensity-modulated radiotherapy. Survival outcomes, the pattern of failures, toxicity, and predictors for survival outcomes were evaluated. Results  A total of 110 patients were included, 65 in the induction group and 45 in the no-induction group. There were no significant differences in the DFS and overall survival (OS) at 3 years between the two groups. On multivariate analysis, performance status (1 vs. 0) predicted worse OS. The 3-year cumulative incidence rates for local, regional, and distant failures were 58.5% (95% confidence interval [CI]: 8.4–89%), 58.00% (95% CI: 8–88.8%), and 63.90% (95% CI: 14.1–90.2%), respectively. IC had more frequent acute grade (G) II anemia (13 vs. 1, p  < 0.01), late G II brain toxicity (4 vs. 1, p  < 0.01), and late G II dysphagia (32 vs. 11, p  = 0.01). Conclusions  Survival outcomes were comparable between the two groups. IC had more frequent acute G II anemia and late G II brain and esophageal toxicities. Thieme Medical and Scientific Publishers Pvt. Ltd. 2022-02-27 /pmc/articles/PMC9803531/ /pubmed/36588606 http://dx.doi.org/10.1055/s-0042-1742724 Text en MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Mohamad, Issa
Abu-Hijleh, Fawzi
Mayta, Ebrahim
Abu-Hejleh, Taher
Al-Gargaz, Wisam
Al Mousa, Abdellatif
Abu-Hijlih, Ramiz
Hosni, Ali
Comparison of Two Standard Treatment Approaches in Locoregionally Advanced Nasopharyngeal Carcinoma
title Comparison of Two Standard Treatment Approaches in Locoregionally Advanced Nasopharyngeal Carcinoma
title_full Comparison of Two Standard Treatment Approaches in Locoregionally Advanced Nasopharyngeal Carcinoma
title_fullStr Comparison of Two Standard Treatment Approaches in Locoregionally Advanced Nasopharyngeal Carcinoma
title_full_unstemmed Comparison of Two Standard Treatment Approaches in Locoregionally Advanced Nasopharyngeal Carcinoma
title_short Comparison of Two Standard Treatment Approaches in Locoregionally Advanced Nasopharyngeal Carcinoma
title_sort comparison of two standard treatment approaches in locoregionally advanced nasopharyngeal carcinoma
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9803531/
https://www.ncbi.nlm.nih.gov/pubmed/36588606
http://dx.doi.org/10.1055/s-0042-1742724
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