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ROMA Index Is an Effective Predictor for Advanced Endometrial Cancer before Surgery
There is a high rate of inconformity between clinical staging and surgical-pathologic staging in endometrial cancer. Many patients with advanced endometrial cancer are preoperatively understaged and thereby do not receive the optimal therapy. Here, we aimed to develop a predictive model or biomarker...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9803563/ https://www.ncbi.nlm.nih.gov/pubmed/36590753 http://dx.doi.org/10.1155/2022/7409368 |
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author | Wang, Jianzhang Xu, Ping Zou, Gen Yin, Meichen Mao, Xinqi Zhang, Xinmei |
author_facet | Wang, Jianzhang Xu, Ping Zou, Gen Yin, Meichen Mao, Xinqi Zhang, Xinmei |
author_sort | Wang, Jianzhang |
collection | PubMed |
description | There is a high rate of inconformity between clinical staging and surgical-pathologic staging in endometrial cancer. Many patients with advanced endometrial cancer are preoperatively understaged and thereby do not receive the optimal therapy. Here, we aimed to develop a predictive model or biomarker for preoperative diagnosis of advanced endometrial cancer via multivariate logistic regression analysis. In this study, 259 eligible patients were included, and 195 patients were assigned to the training dataset and 64 patients to validation dataset. Age, menopause status, sterilization situation, parity, body mass index, hypertension, diabetes mellitus, tumor size, and ovarian malignancy algorithm (ROMA) index were included as predictive variables, and the binary outcome was advanced endometrial cancer or not. When the P value was set as less than 0.01 in forward stepwise regression, only ROMA index was retained. The odds ratio of being positive ROMA index was 15.531 times that of negative value. The area under receiver operating characteristic curve was 0.790 in the training dataset and 0.776 in the validation dataset. The decision curve analysis curve showed that the prediction by ROMA index added more net benefits for almost all threshold probabilities. Therefore, ROMA index is an effective predictor for advanced endometrial cancer before surgery. Since ROMA index is a standard, measurable, and reliable laboratory test, it can be used as a reference tool for gynecologists to design the appropriate therapeutic schedule for patients with high-stage endometrial cancer before surgery. |
format | Online Article Text |
id | pubmed-9803563 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-98035632022-12-31 ROMA Index Is an Effective Predictor for Advanced Endometrial Cancer before Surgery Wang, Jianzhang Xu, Ping Zou, Gen Yin, Meichen Mao, Xinqi Zhang, Xinmei Dis Markers Research Article There is a high rate of inconformity between clinical staging and surgical-pathologic staging in endometrial cancer. Many patients with advanced endometrial cancer are preoperatively understaged and thereby do not receive the optimal therapy. Here, we aimed to develop a predictive model or biomarker for preoperative diagnosis of advanced endometrial cancer via multivariate logistic regression analysis. In this study, 259 eligible patients were included, and 195 patients were assigned to the training dataset and 64 patients to validation dataset. Age, menopause status, sterilization situation, parity, body mass index, hypertension, diabetes mellitus, tumor size, and ovarian malignancy algorithm (ROMA) index were included as predictive variables, and the binary outcome was advanced endometrial cancer or not. When the P value was set as less than 0.01 in forward stepwise regression, only ROMA index was retained. The odds ratio of being positive ROMA index was 15.531 times that of negative value. The area under receiver operating characteristic curve was 0.790 in the training dataset and 0.776 in the validation dataset. The decision curve analysis curve showed that the prediction by ROMA index added more net benefits for almost all threshold probabilities. Therefore, ROMA index is an effective predictor for advanced endometrial cancer before surgery. Since ROMA index is a standard, measurable, and reliable laboratory test, it can be used as a reference tool for gynecologists to design the appropriate therapeutic schedule for patients with high-stage endometrial cancer before surgery. Hindawi 2022-12-23 /pmc/articles/PMC9803563/ /pubmed/36590753 http://dx.doi.org/10.1155/2022/7409368 Text en Copyright © 2022 Jianzhang Wang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Wang, Jianzhang Xu, Ping Zou, Gen Yin, Meichen Mao, Xinqi Zhang, Xinmei ROMA Index Is an Effective Predictor for Advanced Endometrial Cancer before Surgery |
title | ROMA Index Is an Effective Predictor for Advanced Endometrial Cancer before Surgery |
title_full | ROMA Index Is an Effective Predictor for Advanced Endometrial Cancer before Surgery |
title_fullStr | ROMA Index Is an Effective Predictor for Advanced Endometrial Cancer before Surgery |
title_full_unstemmed | ROMA Index Is an Effective Predictor for Advanced Endometrial Cancer before Surgery |
title_short | ROMA Index Is an Effective Predictor for Advanced Endometrial Cancer before Surgery |
title_sort | roma index is an effective predictor for advanced endometrial cancer before surgery |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9803563/ https://www.ncbi.nlm.nih.gov/pubmed/36590753 http://dx.doi.org/10.1155/2022/7409368 |
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