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Current methods of preventing infectious disease and managing febrile neutropenia in childhood cancer patients: a nationwide survey in Japan

BACKGROUND: Preventing infection and managing febrile neutropenia (FN) is mandatory for children with cancer undergoing chemotherapy. However, the current situation in Japan is unknown. METHODS: We conducted a nationwide web-based questionnaire survey in 153 institutions treating childhood cancer in...

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Autores principales: Osone, Shinya, Shinoda, Kunihiro, Yamamoto, Nobuyuki, Suzuki, Koji, Yano, Michihiro, Ishida, Yuji, Saito, Yuya, Sawada, Akihisa, Sano, Hirozumi, Kato, Yoko, Shinkoda, Yuichi, Kakazu, Mariko, Mori, Naoko, Mizutani, Shuki, Fukushima, Keitaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9803594/
https://www.ncbi.nlm.nih.gov/pubmed/36585538
http://dx.doi.org/10.1007/s10147-022-02282-x
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author Osone, Shinya
Shinoda, Kunihiro
Yamamoto, Nobuyuki
Suzuki, Koji
Yano, Michihiro
Ishida, Yuji
Saito, Yuya
Sawada, Akihisa
Sano, Hirozumi
Kato, Yoko
Shinkoda, Yuichi
Kakazu, Mariko
Mori, Naoko
Mizutani, Shuki
Fukushima, Keitaro
author_facet Osone, Shinya
Shinoda, Kunihiro
Yamamoto, Nobuyuki
Suzuki, Koji
Yano, Michihiro
Ishida, Yuji
Saito, Yuya
Sawada, Akihisa
Sano, Hirozumi
Kato, Yoko
Shinkoda, Yuichi
Kakazu, Mariko
Mori, Naoko
Mizutani, Shuki
Fukushima, Keitaro
author_sort Osone, Shinya
collection PubMed
description BACKGROUND: Preventing infection and managing febrile neutropenia (FN) is mandatory for children with cancer undergoing chemotherapy. However, the current situation in Japan is unknown. METHODS: We conducted a nationwide web-based questionnaire survey in 153 institutions treating childhood cancer in Japan. We asked about the type prophylaxis used to prevent infectious disease and manage FN. If patients with childhood cancer were managed by both pediatricians and surgeons at the same institution, we asked both to reply. RESULTS: We received replies from 117 departments at 111 centers: of these, 108 were from pediatricians. Laminar air flow for neutropenic patients, and frequent hand sanitization with ethanol, were widespread. Twenty-eight percent and forty percent of departments performed active surveillance by taking cultures from patients and the environment, respectively, before initiation of chemotherapy. Forty-four percent of departments administered prophylactic intravenous antibiotics according to patient status. Many departments measured serum (1,3)-β-D glucan, procalcitonin, and aspergillus galactomannan at the onset of FN. Twenty-eight percent of departments used carbapenem as empirical therapy for FN. Some departments used prophylactic granulocyte-colony stimulating factor for acute leukemia. Seventy-two percent of departments used prophylactic immunoglobulin for hypogammaglobinemia caused by chemotherapy. Palivizumab was administered widely for respiratory syncytial virus prophylaxis in immunocompromised infants. CONCLUSION: As a whole, intensive care for infectious prophylaxis or FN is applied in Japan; however, the methods vary among centers, and some are excessive or inadequate. Therefore, it is desirable to conduct clinical trials and establish adequate care protocols for infection in children with cancer in Japan. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10147-022-02282-x.
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spelling pubmed-98035942023-01-04 Current methods of preventing infectious disease and managing febrile neutropenia in childhood cancer patients: a nationwide survey in Japan Osone, Shinya Shinoda, Kunihiro Yamamoto, Nobuyuki Suzuki, Koji Yano, Michihiro Ishida, Yuji Saito, Yuya Sawada, Akihisa Sano, Hirozumi Kato, Yoko Shinkoda, Yuichi Kakazu, Mariko Mori, Naoko Mizutani, Shuki Fukushima, Keitaro Int J Clin Oncol Original Article BACKGROUND: Preventing infection and managing febrile neutropenia (FN) is mandatory for children with cancer undergoing chemotherapy. However, the current situation in Japan is unknown. METHODS: We conducted a nationwide web-based questionnaire survey in 153 institutions treating childhood cancer in Japan. We asked about the type prophylaxis used to prevent infectious disease and manage FN. If patients with childhood cancer were managed by both pediatricians and surgeons at the same institution, we asked both to reply. RESULTS: We received replies from 117 departments at 111 centers: of these, 108 were from pediatricians. Laminar air flow for neutropenic patients, and frequent hand sanitization with ethanol, were widespread. Twenty-eight percent and forty percent of departments performed active surveillance by taking cultures from patients and the environment, respectively, before initiation of chemotherapy. Forty-four percent of departments administered prophylactic intravenous antibiotics according to patient status. Many departments measured serum (1,3)-β-D glucan, procalcitonin, and aspergillus galactomannan at the onset of FN. Twenty-eight percent of departments used carbapenem as empirical therapy for FN. Some departments used prophylactic granulocyte-colony stimulating factor for acute leukemia. Seventy-two percent of departments used prophylactic immunoglobulin for hypogammaglobinemia caused by chemotherapy. Palivizumab was administered widely for respiratory syncytial virus prophylaxis in immunocompromised infants. CONCLUSION: As a whole, intensive care for infectious prophylaxis or FN is applied in Japan; however, the methods vary among centers, and some are excessive or inadequate. Therefore, it is desirable to conduct clinical trials and establish adequate care protocols for infection in children with cancer in Japan. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10147-022-02282-x. Springer Nature Singapore 2022-12-31 2023 /pmc/articles/PMC9803594/ /pubmed/36585538 http://dx.doi.org/10.1007/s10147-022-02282-x Text en © The Author(s) under exclusive licence to Japan Society of Clinical Oncology 2022, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Article
Osone, Shinya
Shinoda, Kunihiro
Yamamoto, Nobuyuki
Suzuki, Koji
Yano, Michihiro
Ishida, Yuji
Saito, Yuya
Sawada, Akihisa
Sano, Hirozumi
Kato, Yoko
Shinkoda, Yuichi
Kakazu, Mariko
Mori, Naoko
Mizutani, Shuki
Fukushima, Keitaro
Current methods of preventing infectious disease and managing febrile neutropenia in childhood cancer patients: a nationwide survey in Japan
title Current methods of preventing infectious disease and managing febrile neutropenia in childhood cancer patients: a nationwide survey in Japan
title_full Current methods of preventing infectious disease and managing febrile neutropenia in childhood cancer patients: a nationwide survey in Japan
title_fullStr Current methods of preventing infectious disease and managing febrile neutropenia in childhood cancer patients: a nationwide survey in Japan
title_full_unstemmed Current methods of preventing infectious disease and managing febrile neutropenia in childhood cancer patients: a nationwide survey in Japan
title_short Current methods of preventing infectious disease and managing febrile neutropenia in childhood cancer patients: a nationwide survey in Japan
title_sort current methods of preventing infectious disease and managing febrile neutropenia in childhood cancer patients: a nationwide survey in japan
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9803594/
https://www.ncbi.nlm.nih.gov/pubmed/36585538
http://dx.doi.org/10.1007/s10147-022-02282-x
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