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DNA amplification tests at universal pre-admission screening with enhanced precaution strategies for asymptomatic patients with COVID-19

OBJECTIVE: To analyse the effect of hospital pre-admission screening and enhanced precaution strategies on the transmission of severe acute respiratory syndrome coronavirus-2. METHODS: This retrospective cohort study was conducted over 17 months from 11 May 2020 to 30 September 2021 at a large hospi...

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Detalles Bibliográficos
Autores principales: Nakamura, Itaru, Watanabe, Yusuke, Fujita, Hiroaki, Kobayashi, Takehito, Watanabe, Hidehiro, Itoi, Takao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9803604/
https://www.ncbi.nlm.nih.gov/pubmed/36618878
http://dx.doi.org/10.1016/j.ijregi.2022.12.010
Descripción
Sumario:OBJECTIVE: To analyse the effect of hospital pre-admission screening and enhanced precaution strategies on the transmission of severe acute respiratory syndrome coronavirus-2. METHODS: This retrospective cohort study was conducted over 17 months from 11 May 2020 to 30 September 2021 at a large hospital in Tokyo. Universal DNA amplification tests were conducted during pre-admission screening, and enhanced precaution strategies were implemented for all patients with negative admission tests. The primary outcome was the occurrence of symptomatic coronavirus disease 2019 (COVID-19) in patients after admission. The secondary outcomes were time-series analyses of monthly positive admission test numbers, positive rates, clinical features in positive cases, and clinically confirmed nosocomial transmission. RESULTS: In total, 32,081 patients were screened pre-admission (29,556 asymptomatic patients and 2525 symptomatic patients). Of the asymptomatic patients, 0.11% (n=32) tested positive and were admitted to a designated COVID-19 ward or were not admitted. Among the five inpatients who developed symptomatic COVID-19 during hospitalization, only two cases were related to a single nosocomial transmission. CONCLUSION: Pre-admission test screening was effective in identifying asymptomatic cases of COVID-19. This allowed administrators to quarantine patients or delay hospital admission. The combination of testing and enhanced precaution strategies for asymptomatic cases of COVID-19 may minimize nosocomial transmission.