Cargando…

Increased mitochondrial proton leak and glycolysis in peripheral blood mononuclear cells in type-1-diabetes

Changes in cellular bioenergetics such as mitochondrial respiration and glycolysis may play a role in the pathogenesis of various diseases including type 1 diabetes (T1D). We used Seahorse extracellular flux technology to analyse the efficiency of glycolysis and mitochondrial oxidative phosphorylati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lopes de Melo, Joana Mendes, Laursen, Jens Christian, Søndergaard-Heinrich, Niels, Bull Rasmussen, Ida Kirstine, Hansen, Christian Stevns, Frimodt-Møller, Marie, Rossing, Peter, Størling, Joachim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9803776/ https://www.ncbi.nlm.nih.gov/pubmed/36593831 http://dx.doi.org/10.1016/j.heliyon.2022.e12304

Ejemplares similares

Acute effects of dapagliflozin on renal oxygenation and perfusion in type 1 diabetes with albuminuria: A randomised, double-blind, placebo-controlled crossover trial
por: Laursen, Jens Christian, et al.
Publicado: (2021)

Kidney oxygenation, perfusion and blood flow in people with and without type 1 diabetes
por: Laursen, Jens Christian, et al.
Publicado: (2022)

Persons with type 1 diabetes have low blood oxygen levels in the supine and standing body positions
por: Laursen, Jens Christian, et al.
Publicado: (2021)

The Association Between Cardiovascular Autonomic Function and Changes in Kidney and Myocardial Function in Type 2 Diabetes and Healthy Controls
por: Laursen, Jens Christian, et al.
Publicado: (2021)

Patients with type 1 diabetes and albuminuria have a reduced brain glycolytic capability that is correlated with brain atrophy
por: Vestergaard, Mark B., et al.
Publicado: (2023)

Characterization of the functional and transcriptomic effects of pro-inflammatory cytokines on human EndoC-βH5 beta cells
por: Frørup, Caroline, et al.
Publicado: (2023)

The effect of needle tenotomy on hammer, mallet and claw toe deformities in patients with diabetes, a retrospective study
por: Hedegaard Andersen, Jonas, et al.
Publicado: (2019)

Mitigating risk of aldosterone in diabetic kidney disease
por: Frimodt-Møller, Marie, et al.
Publicado: (2020)

Inflammation Leads the Way on the ROADMAP to Diabetic Kidney Disease
por: Persson, Frederik, et al.
Publicado: (2019)

The urine microbiome – Contamination or a novel paradigm?
por: Frimodt-Møller, Niels
Publicado: (2019)

Mecillinam – Reversion of Resistance and How to Test It
por: Frimodt-Moller, Niels
Publicado: (2017)

Novel topical allogeneic bone-marrow-derived mesenchymal stem cell treatment of hard-to-heal diabetic foot ulcers: a proof of concept study
por: Askø Andersen, Jonas, et al.
Publicado: (2022)

Linking Kidney and Cardiovascular Complications in Diabetes—Impact on Prognostication and Treatment: The 2019 Edwin Bierman Award Lecture
por: Rossing, Peter, et al.
Publicado: (2021)

Beta-Lactamase Producing Escherichia coli Isolates in Imported and Locally Produced Chicken Meat from Ghana
por: Rasmussen, Mette Marie, et al.
Publicado: (2015)

The ostomy leak impact tool: development and validation of a new patient-reported tool to measure the burden of leakage in ostomy device users
por: Nafees, Beenish, et al.
Publicado: (2018)

Influence of the blood bacterial load on the meningeal inflammatory response in Streptococcus pneumoniae meningitis
por: ∅stergaard, Christian, et al.
Publicado: (2006)

Hospital-Diagnosed Infections, Autoimmune Diseases, and Subsequent Dementia Incidence
por: Janbek, Janet, et al.
Publicado: (2023)

Normative data on cardiovascular autonomic function in Greenlandic Inuit
por: Christensen, Marie Mathilde Bjerg, et al.
Publicado: (2021)

Comparative Evaluation of Inoculation of Urine Samples with the Copan WASP and BD Kiestra InoqulA Instruments
por: Iversen, Jesper, et al.
Publicado: (2016)

Carriage and serotype distribution of Streptococcus agalactiae in third trimester pregnancy in southern Ghana
por: Slotved, Hans-Christian, et al.
Publicado: (2017)

A case report of polymicrobial bacteremia with Weissella confusa and comparison of previous treatment for successful recovery with a review of the literature
por: Spiegelhauer, Malene Roed, et al.
Publicado: (2020)

Interplay in the Selection of Fluoroquinolone Resistance and Bacterial Fitness
por: Marcusson, Linda L., et al.
Publicado: (2009)

Cardiovascular autonomic neuropathy and the impact on progression of diabetic kidney disease in type 1 diabetes
por: Bjerre-Christensen, Theis, et al.
Publicado: (2021)

212. Outcomes of Adults with Uncomplicated Staphylococcus aureus Bacteremia Receiving Short-Course Vs. Prolonged-Course Antibiotic Therapy in a Multicenter, Propensity Score–Matched Cohort
por: Thorlacius-Ussing, Louise, et al.
Publicado: (2019)

Chicken IgY reduces the risk of Pseudomonas aeruginosa urinary tract infections in a murine model
por: Schwartz, Franziska A., et al.
Publicado: (2022)

Type 1 Diabetes Candidate Genes Linked to Pancreatic Islet Cell Inflammation and Beta-Cell Apoptosis
por: Størling, Joachim, et al.
Publicado: (2017)

SUN-343 Mortality in Pheochromocytoma after Radical Surgery: Danish National Data over a Period of 40 Years
por: Ebbehøj, Andreas, et al.
Publicado: (2019)

Comparison of two commercial broad-range PCR and sequencing assays for identification of bacteria in culture-negative clinical samples
por: Stavnsbjerg, Camilla, et al.
Publicado: (2017)

Asymptomatic Bacteriuria (ABU) in Elderly: Prevalence, Virulence, Phylogeny, Antibiotic Resistance and Complement C3 in Urine
por: Leihof, Rikke Fleron, et al.
Publicado: (2021)

1428. Increased Consumption of Pivmecillinam in Primary Care for Uncomplicated Urinary Tract Infection (uUTI) Is Not Associated With Increased Resistance Rates
por: Larsen, Anders Rhod, et al.
Publicado: (2021)

The Normal Movements of the Colon after Barium Meal in Indians and Europeans
por: Frimodt-Möller,
Publicado: (1945)

Optimizing recovery of frozen human peripheral blood mononuclear cells for flow cytometry
por: Hønge, Bo Langhoff, et al.
Publicado: (2017)

In vivo study of experimental pneumococcal meningitis using magnetic resonance imaging
por: Brandt, Christian T, et al.
Publicado: (2008)

Lipidomic analysis reveals sphingomyelin and phosphatidylcholine species associated with renal impairment and all-cause mortality in type 1 diabetes
por: Tofte, Nete, et al.
Publicado: (2019)

Endothelial glycocalyx and cardio-renal risk factors in type 1 diabetes
por: Stougaard, Elisabeth Buur, et al.
Publicado: (2021)

The efficacy of pivmecillinam: 3 days or 5 days t.i.d against community acquired uncomplicated lower urinary tract infections – a randomized, double-blinded, placebo-controlled clinical trial study protocol
por: Jansåker, Filip, et al.
Publicado: (2016)

Inflammasomes and Their Role in Innate Immunity of Sexually Transmitted Infections
por: Verma, Vivek, et al.
Publicado: (2016)

Testing the validity of the Danish urban myth that alcohol can be absorbed through feet: open labelled self experimental study
por: Hansen, Christian Stevns, et al.
Publicado: (2010)

Effect of liraglutide on expression of inflammatory genes in type 2 diabetes
por: Zobel, Emilie H., et al.
Publicado: (2021)

Oral ketone esters acutely improve myocardial contractility in post-hospitalized COVID-19 patients: A randomized placebo-controlled double-blind crossover study
por: Wodschow, Helena Zander, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_phuq7a32d6idljidsuish76vf1