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The scaffolding function of LSD1/KDM1A reinforces a negative feedback loop to repress stem cell gene expression during primitive hematopoiesis

Lsd1/Kdm1a functions both as a histone demethylase enzyme and as a scaffold for assembling chromatin modifier and transcription factor complexes to regulate gene expression. The relative contributions of Lsd1’s demethylase and scaffolding functions during embryogenesis are not known. Here, we analyz...

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Detalles Bibliográficos
Autores principales:	Casey, Mattie J., Call, Alexandra M., Thorpe, Annika V., Jette, Cicely A., Engel, Michael E., Stewart, Rodney A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9803847/ https://www.ncbi.nlm.nih.gov/pubmed/36594016 http://dx.doi.org/10.1016/j.isci.2022.105737

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