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Temporal regulation of head-on transcription at replication initiation sites

Head-on (HO) collisions between the DNA replication machinery and RNA polymerase over R-loop forming sequences (RLFS) are genotoxic, leading to replication fork blockage and DNA breaks. Current models suggest that HO collisions are avoided through replication initiation site (RIS) positioning upstre...

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Detalles Bibliográficos
Autores principales:	Kronenberg, Michael, Carey, Michael F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9803852/ https://www.ncbi.nlm.nih.gov/pubmed/36594032 http://dx.doi.org/10.1016/j.isci.2022.105791

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