Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles

Most drug molecules target proteins. Identification of the exact drug binding sites on these proteins is essential to understand and predict how drugs affect protein structure and function. To address this challenge, we developed a strategy that uses immobilized metal-affinity chromatography–enricha...

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Detalles Bibliográficos
Autores principales: van Bergen, Wouter, Hevler, Johannes F., Wu, Wei, Baggelaar, Marc P., Heck, Albert J.R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9803953/
https://www.ncbi.nlm.nih.gov/pubmed/36435334
http://dx.doi.org/10.1016/j.mcpro.2022.100455

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