Targeting ANGPTL3 by GalNAc-conjugated siRNA ANGsiR10 lowers blood lipids with long-lasting and potent efficacy in mice and monkeys

Angiopoietin-like protein 3 (ANGPTL3) is an important regulator of lipoproteins by inhibiting both lipoprotein and endothelial lipases. It has been intensively investigated as a drug target for the treatment of dyslipidemia. In the present study, a modified small interfering RNA (siRNA) conjugated w...

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Detalles Bibliográficos
Autores principales: Wang, Jue, Zheng, Wen, Zheng, Shuquan, Yuan, Ye, Wen, Wei, Cui, Weiyi, Xue, Lifang, Sun, Xueting, Shang, Haibao, Zhang, Hongyan, Xiao, Rui-Ping, Gao, Shan, Zhang, Xiuqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804015/
https://www.ncbi.nlm.nih.gov/pubmed/36618267
http://dx.doi.org/10.1016/j.omtn.2022.11.023

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