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Investigating the Role of DUSP4 in Uveal Melanoma

PURPOSE: Dual-specificity phosphatase 4 (DUSP4) inactivates factors in the mitogen-activated protein kinase (MAPK) signaling cascade, activated in uveal melanoma (UM) by mutations in upstream G-protein α subunits GNAQ/11 in >90% cases. This study examined whether DUSP4 (1) protein expression in p...

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Detalles Bibliográficos
Autores principales:	Aughton, Karen, Sabat-Pośpiech, Dorota, Barlow, Samantha, Coupland, Sarah E., Kalirai, Helen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2022
Materias:	Ocular Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804032/ https://www.ncbi.nlm.nih.gov/pubmed/36576731 http://dx.doi.org/10.1167/tvst.11.12.13

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