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Overexpression of Homer1b/c induces valproic acid resistance in epilepsy

AIMS: Resistance to valproic acid (VPA) is a major challenge for epilepsy treatment. We aimed to explore the mechanism underlying this resistance. METHODS: Pentylenetetrazol‐induced chronic epileptic rats were administered VPA (250 mg/Kg) for 14 days; rats with controlled seizure stages (seizure sco...

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Detalles Bibliográficos
Autores principales: Wang, Yan, Li, Youbin, Wang, Guangfei, Lu, Jinmiao, Li, Zhiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804053/
https://www.ncbi.nlm.nih.gov/pubmed/36353757
http://dx.doi.org/10.1111/cns.14008