A new triphenylphosphonium-conjugated amphipathic cationic peptide with improved cell-penetrating and ROS-targeting properties

We study for the first time whether triphenylphosphonium (TPP) moiety can improve cellular delivery and redox properties of amphipathic cationic peptides based on YRFK/YrFK cell-penetrating and cytoprotective motif. TPP moiety was found to increase reducing activity of both stereoisomeric peptides i...

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Detalles Bibliográficos
Autores principales: Ishkaeva, Rezeda A., Salakhieva, Diana V., Garifullin, Ruslan, Alshadidi, Raghad, Laikov, Alexander V., Yergeshov, Abdulla A., Kamalov, Marat I., Abdullin, Timur I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804109/
https://www.ncbi.nlm.nih.gov/pubmed/36593927
http://dx.doi.org/10.1016/j.crphar.2022.100148

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