Predictors of serious adverse events and non‐response in cirrhotic patients with primary biliary cholangitis treated with obeticholic acid

BACKGROUND & AIMS: Obeticholic acid (OCA) has recently been restricted in patients with primary biliary cholangitis (PBC) with “advanced cirrhosis” because of its narrow therapeutic index. We aimed to better define the predicting factors of hepatic serious adverse events (SAEs) and non‐response...

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Autores principales: De Vincentis, Antonio, D'Amato, Daphne, Cristoferi, Laura, Gerussi, Alessio, Malinverno, Federica, Lleo, Ana, Colapietro, Francesca, Marra, Fabio, Galli, Andrea, Fiorini, Cecilia, Coco, Barbara, Brunetto, Maurizia, Niro, Grazia Anna, Cotugno, Rosa, Saitta, Carlo, Cozzolongo, Raffaele, Losito, Francesco, Giannini, Edoardo Giovanni, Labanca, Sara, Marzioni, Marco, Marconi, Giulia, Morgando, Anna, Pellicano, Rinaldo, Vanni, Ester, Cazzagon, Nora, Floreani, Annarosa, Chessa, Luchino, Morelli, Olivia, Muratori, Luigi, Pellicelli, Adriano, Pompili, Maurizio, Ponziani, Francesca, Tortora, Annalisa, Rosina, Floriano, Russello, Maurizio, Cannavò, Mariarita, Simone, Loredana, Storato, Silvia, Viganò, Mauro, Abenavoli, Ludovico, D'Antò, Maria, De Gasperi, Elisabetta, Distefano, Marco, Scifo, Gaetano, Zolfino, Teresa, Calvaruso, Vincenza, Cuccorese, Giuseppe, Palitti, Valeria Pace, Sacco, Rodolfo, Bertino, Gaetano, Frazzetto, Evelise, Alvaro, Domenico, Mulinacci, Giacomo, Palermo, Andrea, Scaravaglio, Miki, Terracciani, Francesca, Galati, Giovanni, Ronca, Vincenzo, Zuin, Massimo, Claar, Ernesto, Izzi, Antonio, Picardi, Antonio, Invernizzi, Pietro, Vespasiani‐Gentilucci, Umberto, Carbone, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Gut‐liver Axis, Immunology, Immune Mediated and Cholestatic Diseases
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804305/
https://www.ncbi.nlm.nih.gov/pubmed/35932095
http://dx.doi.org/10.1111/liv.15386

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