Characterization of interaction between blood coagulation factor VIII and LRP1 suggests dynamic binding by alternating complex contacts

BACKGROUND: Deficiency in blood coagulation factor VIII (FVIII) results in life‐threating bleeding (hemophilia A) treated by infusions of FVIII concentrates. To improve disease treatment, FVIII has been modified to increase its plasma half‐life, which requires understanding mechanisms of FVIII catab...

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Detalles Bibliográficos
Autores principales: Chun, Haarin, Kurasawa, James H., Olivares, Philip, Marakasova, Ekaterina S., Shestopal, Svetlana A., Hassink, Gabriela U., Karnaukhova, Elena, Migliorini, Mary, Obi, Juliet O., Smith, Ally K., Wintrode, Patrick L., Durai, Prasannavenkatesh, Park, Keunwan, Deredge, Daniel, Strickland, Dudley K., Sarafanov, Andrey G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
HAEMOSTASIS
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804390/
https://www.ncbi.nlm.nih.gov/pubmed/35810466
http://dx.doi.org/10.1111/jth.15817

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