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Organic Anion Transporter Gene Variants Associated With Plasma Exposure and Long‐Term Response to Atrasentan in Patients With Diabetic Kidney Disease

Plasma exposure of the endothelin receptor antagonist atrasentan varies between individuals and is associated with nephroprotective effects and the risk of heart failure. We examined the influence of genetic polymorphisms on atrasentan plasma exposure and pharmacodynamic effects. We performed a subs...

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Detalles Bibliográficos
Autores principales:	Smeijer, J. David, Koomen, Jeroen V., Kohan, Donald E., McMurray, John J. V., Bakris, George L., Correa‐Rotter, Ricardo, Hou, Fan‐Fan, Kitzman, Dalane W., Makino, Hirofumi, Mayer, Gert, Nowicki, Michal, Perkovic, Vlado, Rossing, Peter, Tobe, Sheldon, Parving, Hans‐Henrik, de Zeeuw, Dick, Heerspink, Hiddo J. L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804438/ https://www.ncbi.nlm.nih.gov/pubmed/35892316 http://dx.doi.org/10.1002/cpt.2721

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