Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers

Skin cancers are by far the most frequently diagnosed human cancers. The closely related transcriptional co‐regulator proteins YAP and TAZ (WWTR1) have emerged as important drivers of tumour initiation, progression and metastasis in melanoma and non‐melanoma skin cancers. YAP/TAZ serve as an essenti...

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Detalles Bibliográficos
Autores principales: Howard, Alexander, Bojko, Jodie, Flynn, Benjamin, Bowen, Sophie, Jungwirth, Ute, Walko, Gernot
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804452/
https://www.ncbi.nlm.nih.gov/pubmed/35913427
http://dx.doi.org/10.1111/exd.14655
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author Howard, Alexander
Bojko, Jodie
Flynn, Benjamin
Bowen, Sophie
Jungwirth, Ute
Walko, Gernot
author_facet Howard, Alexander
Bojko, Jodie
Flynn, Benjamin
Bowen, Sophie
Jungwirth, Ute
Walko, Gernot
author_sort Howard, Alexander
collection PubMed
description Skin cancers are by far the most frequently diagnosed human cancers. The closely related transcriptional co‐regulator proteins YAP and TAZ (WWTR1) have emerged as important drivers of tumour initiation, progression and metastasis in melanoma and non‐melanoma skin cancers. YAP/TAZ serve as an essential signalling hub by integrating signals from multiple upstream pathways. In this review, we summarize the roles of YAP/TAZ in skin physiology and tumorigenesis and discuss recent efforts of therapeutic interventions that target YAP/TAZ in in both preclinical and clinical settings, as well as their prospects for use as skin cancer treatments.
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spelling pubmed-98044522023-01-03 Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers Howard, Alexander Bojko, Jodie Flynn, Benjamin Bowen, Sophie Jungwirth, Ute Walko, Gernot Exp Dermatol Review Articles Skin cancers are by far the most frequently diagnosed human cancers. The closely related transcriptional co‐regulator proteins YAP and TAZ (WWTR1) have emerged as important drivers of tumour initiation, progression and metastasis in melanoma and non‐melanoma skin cancers. YAP/TAZ serve as an essential signalling hub by integrating signals from multiple upstream pathways. In this review, we summarize the roles of YAP/TAZ in skin physiology and tumorigenesis and discuss recent efforts of therapeutic interventions that target YAP/TAZ in in both preclinical and clinical settings, as well as their prospects for use as skin cancer treatments. John Wiley and Sons Inc. 2022-08-12 2022-10 /pmc/articles/PMC9804452/ /pubmed/35913427 http://dx.doi.org/10.1111/exd.14655 Text en © 2022 The Authors. Experimental Dermatology published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Articles
Howard, Alexander
Bojko, Jodie
Flynn, Benjamin
Bowen, Sophie
Jungwirth, Ute
Walko, Gernot
Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers
title Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers
title_full Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers
title_fullStr Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers
title_full_unstemmed Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers
title_short Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers
title_sort targeting the hippo/yap/taz signalling pathway: novel opportunities for therapeutic interventions into skin cancers
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804452/
https://www.ncbi.nlm.nih.gov/pubmed/35913427
http://dx.doi.org/10.1111/exd.14655
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